PIM2

Gene Symbol PIM2
Entrez Gene 11040
Alt Symbol -
Species Human
Gene Type protein-coding
Description Pim-2 proto-oncogene, serine/threonine kinase
Other Description pim-2 oncogene|pim-2h|proto-oncogene Pim-2 (serine threonine kinase)|serine/threonine protein kinase pim-2|serine/threonine-protein kinase pim-2
Swissprots A8K4G6 Q9P1W9 Q99739
Accessions BAA95613 CAH05302 CAH05303 CBX53832 EAW50729 EAW50730 Q9P1W9 AK290931 BAF83620 AK312745 BC018111 AAH18111 DC378253 DQ891336 ABM82262 DQ894518 ABM85444 U77735 AAC78506 XM_011543887 XP_011542189 NM_006875 NP_006866
Function Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of
Tissue Specificity Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues. {ECO:0000269|PubMed:18675992}.
Top Pathways Acute myeloid leukemia

HTScan ® Pim-2 Kinase Assay Kit - 7576 from Cell Signaling Technology

Category Assay Kit
Figure 1. Pim-2 kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, ATP (variable), 2.5 µg/50 µl PEG20,000, Substrate: R11-S6-peptide5 µg/50 µl, recombinant Pim-2: 200 ng/50 µl.

Human PIM2 / Pim-2 ELISA Kit (Sandwich ELISA) - LS-F7736 from LifeSpan Bioscience

Category ELISA Kit
Prices $790.00
Sizes 1 plate
Sensitivity 0.257 ng/ml
Range 0.625-40 ng/ml

Human Pim-2 Oncogene ELISA Kit - abx152745 from Abbexa

Category ELISA Kit
Sensitivity 0.227 ng/ml
Range 0.625 ng/ml - 40 ng/ml

Pim-2 Oncogene (PIM2), Human, ELISA Kit - SEP797Hu from ARP American Research Products

Category ELISA Kit
Prices $790.00
Sizes 96 t
Sensitivity 0.227ng/mL
Range 0.625-40ng/mL

Pim-2 Oncogene (PIM2), Human, CLIA Kit - SCP797Hu from ARP American Research Products

Category CLIA Kit
Prices $840.00
Sizes 96 t
Sensitivity 0.255ng/mL
Range 0.625-40ng/mL

Pim-2 Oncogene, ELISA Kit - MBS092160 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene, ELISA Kit - MBS051459 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene, ELISA Kit - MBS077079 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene, ELISA Kit - MBS053016 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene, ELISA Kit - MBS082759 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene, ELISA Kit - MBS103862 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

pim-2 oncogene, ELISA Kit - MBS9340119 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene, ELISA Kit - MBS100065 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-2 Oncogene (PIM2), ELISA Kit - MBS2020757 from MyBioSource

Category ELISA Kit
Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.257ng/mL.
Range 0.625-40ng/mL

Pim-2 Oncogene (PIM2) ), ELISA Kit - MBS9314036 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Pim-2 Oncogene (PIM2) - SEP797Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.257ng/mL.
Range 0.625-40ng/mL The standard curve concentrations used for the ELISA’s were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

CLIA Kit for Pim-2 Oncogene (PIM2) - SCP797Hu from Uscn Life Science Inc.

Category CLIA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.03ng/mL.
Range 0.055-40ng/mL The standard curve concentrations used for the CLIA’s were 40ng/mL, 13.333ng/mL, 4.444ng/mL, 1.481ng/mL, 0.494ng/mL, 0.165ng/mL, 0.055ng/mL

ELISA Kit for Pim-2 Oncogene (PIM2) - SEP797Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.257ng/mL.
Range 0.625-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

CLIA Kit for Pim-2 Oncogene (PIM2) - SCP797Hu from Cloud-clone

Category CLIA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.03ng/mL.
Range 0.055-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 13.33ng/mL, 4.44ng/mL, 1.48ng/mL, 0.494ng/mL, 0.165ng/mL, 0.055ng/mL

Human Pim-2 Oncogene (PIM2) ELISA Kit - EKU06642 from Biomatik

Category ELISA Kit
Prices $809.00, $3,557.00, $6,468.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.257 ng/mL
Range 0.625-40 ng/mL

Human Pim-2 Oncogene CLIA Kit - abx190021 from Abbexa

Category CLIA Kit
Range 0.055 ng/ml - 40 ng/ml

Pim-2 Oncogene (PIM2), Human, ELISA Kit - DL-PIM2-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 0.625-40 ng/mL

Pim-2 Oncogene (PIM2), CLIA Kit - MBS2001108 from MyBioSource

Category CLIA Kit
Prices $440.00, $655.00, $900.00, $3,705.00, $6,680.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.255 ng/mL
Range 0.625-40 ng/mL

Human PIM2 / Pim-2 ELISA Kit (CLIA) - LS-F25858 from LifeSpan Bioscience

Category ELISA Kit
Prices $930.00
Sizes 1 plate
Sensitivity 0.03 ng/ml
Range 0.625-40 ng/ml

Human PIM2 ELISA Kit - abx573365 from Abbexa

Category ELISA Kit
Sensitivity 0.227 ng/ml
Range 0.625 ng/ml - 40 ng/ml
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