Gene Symbol | ST6GALNAC6 |
---|---|
Entrez Gene | 30815 |
Alt Symbol | SIAT7-F, SIAT7F, ST6GALNACVI |
Species | Human |
Gene Type | protein-coding |
Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
Other Description | CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6|galNAc alpha-2,6-sialyltransferase VI|sialyltransferase 7F|sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F |
Swissprots | Q9ULB8 Q5T9C4 Q5T9C5 B3KQ01 Q969X2 Q9H8A2 |
Accessions | CAS91687 EAW87710 EAW87711 EAW87712 EAW87713 EAW87714 EAW87715 Q969X2 AB035173 BAA87035 AJ507293 CAD45373 AK023900 BAB14715 AK025959 AK057100 BAG51863 AK226174 AK300534 BAG62242 AK310850 AY358672 AAQ89035 BC006564 AAH06564 BC007802 AAH07802 BC016299 AAH16299 BC036102 BG699392 CR457318 CAG33599 JF432648 ADZ15865 XM_011518610 XP_011516912 XM_011518611 XP_011516913 XM_011518612 XP_011516914 XM_011518613 XP_011516915 XM_011518614 XP_011516916 XM_011518615 XP_011516917 XR_929785 XR_929786 NM_001286999 NP_001273928 NM_001287000 NP_001273929 NM_001287001 NP_001273930 NM_001287002 NP_001273931 NM_001287003 NP_001273932 NM_013443 NP_038471 NR_104629 |
Function | Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}. |
Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
Sialyltransferase 7F (P-19) - sc-68816 from Santa Cruz Biotechnology
|
||||||||||
Sialyltransferase 7F (Y-20) - sc-68817 from Santa Cruz Biotechnology
|
||||||||||
Sialyltransferase 7F (E-21) - sc-134001 from Santa Cruz Biotechnology
|
||||||||||
Anti-ST6GALNAC6 antibody - ab104861 from Abcam
|
||||||||||
Anti-ST6GALNAC6 antibody - ab67814 from Abcam
|
||||||||||
Anti-ST6GALNAC6 Antibody (C-Terminus) - LS-C80966 from LifeSpan Bioscience
|
||||||||||
Anti-ST6GALNAC6 Antibody (aa51-100) - LS-C117111 from LifeSpan Bioscience
|
||||||||||
ST6 Sialyltransferase 6/ST6GALNAC6 Antibody - NBP1-59959 from Novus Biologicals
|
||||||||||
ST6 Sialyltransferase 6/ST6GALNAC6 Antibody - NBP1-80751 from Novus Biologicals
|
||||||||||
ST6 Sialyltransferase 6/ST6GALNAC6 Antibody - H00030815-B01P from Novus Biologicals
|
||||||||||
ST6 Sialyltransferase 6/ST6GALNAC6 Antibody - H00030815-B02P from Novus Biologicals
|
||||||||||
ST6 Sialyltransferase 6/ST6GALNAC6 Antibody - H00030815-B01 from Novus Biologicals
|
||||||||||
ST6 Sialyltransferase 6/ST6GALNAC6 Antibody - H00030815-B02 from Novus Biologicals
|
||||||||||
Anti-ST6GALNAC6 antibody produced in rabbit - AV46950 from Sigma-Aldrich
|
||||||||||
Anti-ST6GALNAC6 antibody produced in mouse - SAB1407406 from Sigma-Aldrich
|
||||||||||
Anti-ST6GALNAC6 antibody produced in mouse - SAB1409187 from Sigma-Aldrich
|
||||||||||
ST6GALNAC6 antibody - C-terminal region (ARP46950_P050) - ARP46950_P050 from Aviva Systems Biology
|
||||||||||
ST6GALNAC6 antibody - N-terminal region (ARP46951_P050) - ARP46951_P050 from Aviva Systems Biology
|
||||||||||
ST6GALNAC6 antibody - 70R-6867 from Fitzgerald
|
||||||||||
ST6GALNAC6 antibody - 66209-1-Ig from Acris Antibodies
|
||||||||||
ST6GALNAC6 antibody - H00030815-B01 from Acris Antibodies
|
||||||||||
ST6GALNAC6 antibody - H00030815-B01P from Acris Antibodies
|
||||||||||
ST6GALNAC6 antibody - H00030815-B02 from Acris Antibodies
|
||||||||||
ST6GALNAC6 antibody - H00030815-B02P from Acris Antibodies
|
||||||||||
ST6GALNAC6 Antibody - 30-253 from ProSci
|