Gene Symbol | ST6GALNAC6 |
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Entrez Gene | 30815 |
Alt Symbol | SIAT7-F, SIAT7F, ST6GALNACVI |
Species | Human |
Gene Type | protein-coding |
Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
Other Description | CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6|galNAc alpha-2,6-sialyltransferase VI|sialyltransferase 7F|sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F |
Swissprots | Q9ULB8 Q5T9C4 Q5T9C5 B3KQ01 Q969X2 Q9H8A2 |
Accessions | CAS91687 EAW87710 EAW87711 EAW87712 EAW87713 EAW87714 EAW87715 Q969X2 AB035173 BAA87035 AJ507293 CAD45373 AK023900 BAB14715 AK025959 AK057100 BAG51863 AK226174 AK300534 BAG62242 AK310850 AY358672 AAQ89035 BC006564 AAH06564 BC007802 AAH07802 BC016299 AAH16299 BC036102 BG699392 CR457318 CAG33599 JF432648 ADZ15865 XM_011518610 XP_011516912 XM_011518611 XP_011516913 XM_011518612 XP_011516914 XM_011518613 XP_011516915 XM_011518614 XP_011516916 XM_011518615 XP_011516917 XR_929785 XR_929786 NM_001286999 NP_001273928 NM_001287000 NP_001273929 NM_001287001 NP_001273930 NM_001287002 NP_001273931 NM_001287003 NP_001273932 NM_013443 NP_038471 NR_104629 |
Function | Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}. |
Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
Human ST6GALNAC6 full length protein - ab162318 from Abcam
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Human ST6GALNAC6 full length protein - ab162319 from Abcam
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Human ST6GALNAC6 protein fragment - ab162320 from Abcam
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ST6GALNAC6 Antibody Blocking Peptide - LS-E17064 from LifeSpan Bioscience
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ST6GALNAC6 Antibody Blocking Peptide - LS-E17065 from LifeSpan Bioscience
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Recombinant Human ST6 Sialyltransferase 6/ST6GALNAC6 Protein - H00030815-P01 from Novus Biologicals
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Recombinant Human ST6 Sialyltransferase 6/ST6GALNAC6 Protein - H00030815-P02 from Novus Biologicals
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ST6 Sialyltransferase 6/ST6GALNAC6 Partial Recombinant Protein - H00030815-Q01 from Novus Biologicals
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Recombinant Human ST6GALNAC6, CF - 7425-GT-010 from R&D Systems
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ST6GALNAC6 Blocking Peptide - 33R-1341 from Fitzgerald
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ST6GALNAC6 Blocking Peptide - 33R-10129 from Fitzgerald
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ST6GALNAC6 - H00030815-P01-02 from Acris Antibodies
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ST6GALNAC6 - H00030815-P02 from Acris Antibodies
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ST6GALNAC6 - H00030815-P02-10 from Acris Antibodies
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ST6GALNAC6 - H00030815-P02-25 from Acris Antibodies
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ST6GALNAC6 - H00030815-Q01-10 from Acris Antibodies
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ST6GALNAC6 - H00030815-Q01-25 from Acris Antibodies
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ST6GALNAC6 fusion protein - Ag8475 from Proteintech Group
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ST6GALNAC6 fusion protein - ag8358 from Proteintech Group
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Recombinant Human ST6GALNAC6, GST-tagged - ST6GALNAC6-2980H from Creative Biomart
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Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6(ST6GALNAC6) - CSB-YP850251HU CSB-EP850251HU CSB-BP850251HU CSB-MP850251HU from Cusabio
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Recombinant Human ST6GALNAC6 Protein, CF - 7425-GT from R&D Systems
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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6) - MBS1435633 from MyBioSource
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ST6 Sialyltransferase 6/ST6GALNAC6 Recombinant Protein Antigen - NBP1-80751PEP from Novus Biologicals
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ST6GALNAC6 Peptide, Human - M34GP15247H from Creative Peptides
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