| Gene Symbol | ST6GALNAC6 |
|---|---|
| Entrez Gene | 30815 |
| Alt Symbol | SIAT7-F, SIAT7F, ST6GALNACVI |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
| Other Description | CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6|galNAc alpha-2,6-sialyltransferase VI|sialyltransferase 7F|sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F |
| Swissprots | Q9ULB8 Q5T9C4 Q5T9C5 B3KQ01 Q969X2 Q9H8A2 |
| Accessions | CAS91687 EAW87710 EAW87711 EAW87712 EAW87713 EAW87714 EAW87715 Q969X2 AB035173 BAA87035 AJ507293 CAD45373 AK023900 BAB14715 AK025959 AK057100 BAG51863 AK226174 AK300534 BAG62242 AK310850 AY358672 AAQ89035 BC006564 AAH06564 BC007802 AAH07802 BC016299 AAH16299 BC036102 BG699392 CR457318 CAG33599 JF432648 ADZ15865 XM_011518610 XP_011516912 XM_011518611 XP_011516913 XM_011518612 XP_011516914 XM_011518613 XP_011516915 XM_011518614 XP_011516916 XM_011518615 XP_011516917 XR_929785 XR_929786 NM_001286999 NP_001273928 NM_001287000 NP_001273929 NM_001287001 NP_001273930 NM_001287002 NP_001273931 NM_001287003 NP_001273932 NM_013443 NP_038471 NR_104629 |
| Function | Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}. |
| Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
Sialyltransferase 7F CRISPR/Cas9 KO Plasmid (h) - sc-412069 from Santa Cruz Biotechnology
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Sialyltransferase 7F HDR Plasmid (h) - sc-412069-HDR from Santa Cruz Biotechnology
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Sialyltransferase 7F Double Nickase Plasmid (h) - sc-412069-NIC from Santa Cruz Biotechnology
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Sialyltransferase 7F Double Nickase Plasmid (h2) - sc-412069-NIC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7F CRISPR Activation Plasmid (h) - sc-412069-ACT from Santa Cruz Biotechnology
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Sialyltransferase 7F CRISPR Activation Plasmid (h2) - sc-412069-ACT-2 from Santa Cruz Biotechnology
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Sialyltransferase 7F Lentiviral Activation Particles (h) - sc-412069-LAC from Santa Cruz Biotechnology
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Sialyltransferase 7F Lentiviral Activation Particles (h2) - sc-412069-LAC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7F siRNA (h) - sc-63022 from Santa Cruz Biotechnology
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Sialyltransferase 7F shRNA Plasmid (h) - sc-63022-SH from Santa Cruz Biotechnology
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Sialyltransferase 7F shRNA (h) Lentiviral Particles - sc-63022-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU003541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20667 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20667 from Sigma-Aldrich
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ST6GALNAC6 siRNA (Human) - CRH9342 from Cohesion Biosciences
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ST6GALNAC6 - MBS8204055 from MyBioSource
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shRNA set against Human ST6GALNAC6 (NM_013443.3) - SHH418960 from Creative biogene
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shRNA set against Human ST6GALNAC6(NM_013443.3) - SHR224966 from Creative biogene
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ST6GALNAC6 shRNA Plasmid (Human) - CHH9342 from Cohesion Biosciences
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ST6GALNAC6 miRNA 3'UTR clone - MiUTR1H-09955 from Creative biogene
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