SRC

Gene Symbol	SRC
Entrez Gene	6714
Alt Symbol	ASV, SRC1, c-SRC, p60-Src
Species	Human
Gene Type	protein-coding
Description	SRC proto-oncogene, non-receptor tyrosine kinase
Other Description	proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1|v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Swissprots	Q76P87 E1P5V4 P12931 Q9H5A8 Q86VB9
Accessions	AAA60584 AAB59543 AAC29427 CAA26485 CAN37623 EAW76062 EAW76063 EAW76064 EAW76065 EAW76066 EAW76067 P12931 AF272982 AK024281 BAB14871 AK091756 AW135290 BC011566 AAH11566 BC051270 AAH51270 CD364525 EU831426 ACE87113 EU831519 ACE86438 HY016645 JF432365 ADZ15582 Z18364 XM_011529013 XP_011527315 XM_011529014 XP_011527316 NM_005417 NP_005408 NM_198291 NP_938033
Function	Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasm
Subcellular Location	Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.
Tissue Specificity	Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
Top Pathways	Inflammatory mediator regulation of TRP channels, Proteoglycans in cancer, Rap1 signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SRC 293T Cell Transient Overexpression Lysate(Denatured) - H00006714-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SRC overexpression lysate - LY405010 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SRC overexpression lysate - LY417311 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

Src Overexpression Lysate (Denatured) - H00006714-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Src Overexpression Lysate (Native) - NBP2-07751 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

c-Src (h): 293T Lysate - sc-176936 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

c-Src (h2): 293T Lysate - sc-176937 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Human SRC Kinase / Proto-oncogene c-Src Insect Cell Lysate (WB positive control) - 10755-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Src Overexpression Lysate (Native) - NBP2-04722 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SRC-knockout Cell lysate - LC810224 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human SRC Knockdown Stable Cell Line - CSC-DC015134 from Creative biogene Category Cell Line Species Human

Human SRC Knockout Cell Line-HeLa - CSC-RT0691 from Creative biogene Category Cell Line Species Human

SRC KO Cell Lysate-HeLa - CLKO-0196 from Creative biogene Category Cell Lysate

SRC KO Cell Lysate-HeLa - CLKO-1723 from Creative biogene Category Cell Lysate

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