SRC

Gene Symbol SRC
Entrez Gene 6714
Alt Symbol ASV, SRC1, c-SRC, p60-Src
Species Human
Gene Type protein-coding
Description SRC proto-oncogene, non-receptor tyrosine kinase
Other Description proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1|v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Swissprots Q76P87 E1P5V4 P12931 Q9H5A8 Q86VB9
Accessions AAA60584 AAB59543 AAC29427 CAA26485 CAN37623 EAW76062 EAW76063 EAW76064 EAW76065 EAW76066 EAW76067 P12931 AF272982 AK024281 BAB14871 AK091756 AW135290 BC011566 AAH11566 BC051270 AAH51270 CD364525 EU831426 ACE87113 EU831519 ACE86438 HY016645 JF432365 ADZ15582 Z18364 XM_011529013 XP_011527315 XM_011529014 XP_011527316 NM_005417 NP_005408 NM_198291 NP_938033
Function Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasm
Subcellular Location Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.
Tissue Specificity Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
Top Pathways Inflammatory mediator regulation of TRP channels, Proteoglycans in cancer, Rap1 signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway

Src (36D10) Rabbit mAb (Pacific Blue™ Conjugate) - 13040 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 36D10
Flow cytometric analysis of MCF7 cells using Src (36D10) Rabbit mAb (Pacific Blue™ Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (Pacific Blue™ Conjugate) #9078 (red).

Src (32G6) Rabbit mAb (Biotinylated) - 8077 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 32G6
Western blot analysis of extracts from C2C12 and H-4-II-E cells using Src (32G6) Rabbit mAb (Biotinylated).

Src (36D10) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 12858 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 36D10
Flow cytometric analysis of MCF7 cells using Src (36D10) Rabbit mAb (Alexa Fluor® 647 Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (Alexa Fluor® 647 Conjugate) #2985 (red).

Src (36D10) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 12945 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 36D10
Flow cytometric analysis of MCF7 cells using Src (36D10) Rabbit mAb (Alexa Fluor® 488 Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (Alexa Fluor® 488 Conjugate) #2975 (red).

Src (36D10) Rabbit mAb (Biotinylated) - 8048 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 36D10
Western blot analysis of extracts from C2C12 and H-4-II-E cells using Src (36D10) Rabbit mAb (Biotinylated).

Phospho-Src (Ser17) Antibody - 5473 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C2C12 and MCF7 cells, untreated (-) or treated with λ phosphatase (+), using Phospho-Src (Ser17) Antibody or Src (32G5) Rabbit mAb #2123.

Phospho-Src (Tyr527) Antibody - 2105 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 cells, using Phospho-Src (Tyr527) Antibody (A,B) or v-Src antibody (C,D). The phospho-specificity of the antibody was confirmed by treating the membrane with calf intestinal alkaline phosphatase (CIP) (B,D) after Western transfer.

Phospho-Src (Ser17) (D7F2Q) Rabbit mAb - 12432 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7F2Q
Western blot analysis of extracts from 293T cells, untreated (-) or treated (+) with λ phosphatase and calf intestinal phosphatase (CIP), using Phospho-Src (Ser17) (D7F2Q) Rabbit mAb (upper) or Src (32G6) Rabbit mAb #2123 (lower).

Src Antibody - 2108 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Src Antibody.

Src (36D10) Rabbit mAb - 2109 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 36D10
Western blot analysis of extracts from various cell lines using Src (36D10) Rabbit mAb.

Non-phospho-Src (Tyr527) Antibody - 2107 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431 cells, untreated or pervanadate-treated (1 mM for 15 minutes), using Non-phospho-Src (Tyr527) Antibody (upper) or v-Src antibody (lower).

Src (L4A1) Mouse mAb - 2110 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L4A1
Western blot analysis of cell extracts from various cell lines, using Src (L4A1) Mouse mAb.

Src (32G6) Rabbit mAb - 2123 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 32G6
Western blot analysis of cell extracts from various cell lines, using Src (32G6) Rabbit mAb.

c-Src (5D10C4) - sc-130074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Src (5D10C4): sc-130074. Western blot analysis of truncated human recombinant c-Src-His protein (A) and c-Src expression in PMA treated THP-1 whole cell lysate (B).

c-Src (H-12) - sc-5266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Src (H-12): sc-5266. Western blot analysis of human recombinant c-Src.

c-Src (4F1E8) - sc-130069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Src (4F1E8): sc-130069. Western blot analysis of truncated human recombinant c-Src-His protein (A) and c-Src expression in PMA treated THP-1 whole cell lysate (B).

c-Src (N-16) - sc-19 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Src (N-16) PE: sc-19 PE. Intracellular FCM analysis of fixed and permeabilized H4 cells. Black line histogram represents the isotype control, normal rabbit IgG: sc-3871.

c-Src (17AT28) - sc-130124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
c-Src (17AT28): sc-130124. Western blot analysis of c-Src expression in Jurkat whole cell lysate.

p-c-Src (H-3) - sc-166860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of c-Src phosphorylation in untreated (A,D), serum starved and EGF treated (B,E) and serum starved, EGF and lambda protein phosphatase treated (C,F) HEK293 whole cell lysates. Antibodies tested include p-c-Src (H-3): sc-166860 (A,B,C) and c-Src (17AT28): sc-130124 (D,E,F).

p-c-Src (Tyr 139) - sc-22126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of c-Src phosphorylation in untreated (A, C) and lambda protein phosphatase treated (B, D) A549 whole cell lysates. Antibodies tested include p-c-Src (Tyr 139)-R: sc-22126-R (A, B) and c-Src (SRC 2): sc-18 (C, D).

p-c-Src (H-8) - sc-166859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of c-Src phosphorylation in untreated (A,D), serum starved and EGF treated (B,E) and serum starved, EGF and lambda protein phosphatase treated (C,F) HEK293 whole cell lysates. Antibodies tested include p-c-Src (H-8): sc-166859 (A,B,C) and c-Src (17AT28): sc-130124 (D,E,F).

p-c-Src (Tyr 530) - sc-16846 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-c-Src (Tyr 530)-R: sc-16846-R. Western blot analysis of c-Src phosphorylation in untreated (A), EGF treated (B) and EGF and lambda protein phosphatase treated (C) HEK293 whole cell lysates.

p-c-Src (Tyr 216) - sc-16844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-c-Src (Tyr 419) - sc-101802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-c-Src (Thr 420): sc-101802. Western blot analysis of c-Src phosphorylation in untreated (A), EGF treated (B) and EGF and lambda protein phosphatase (sc-200312A) treated (C) HEK293 whole cell lysates.

p-c-Src (Tyr 530) - sc-101803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-c-Src (Tyr 530): sc-101803. Western blot analysis of phosphorylated c-Src expression in untreated (A) and EGF + serium-treated (B) 293 whole cell lysates.
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