SRC

Gene Symbol SRC
Entrez Gene 6714
Alt Symbol ASV, SRC1, c-SRC, p60-Src
Species Human
Gene Type protein-coding
Description SRC proto-oncogene, non-receptor tyrosine kinase
Other Description proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1|v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Swissprots Q76P87 E1P5V4 P12931 Q9H5A8 Q86VB9
Accessions AAA60584 AAB59543 AAC29427 CAA26485 CAN37623 EAW76062 EAW76063 EAW76064 EAW76065 EAW76066 EAW76067 P12931 AF272982 AK024281 BAB14871 AK091756 AW135290 BC011566 AAH11566 BC051270 AAH51270 CD364525 EU831426 ACE87113 EU831519 ACE86438 HY016645 JF432365 ADZ15582 Z18364 XM_011529013 XP_011527315 XM_011529014 XP_011527316 NM_005417 NP_005408 NM_198291 NP_938033
Function Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasm
Subcellular Location Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.
Tissue Specificity Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
Top Pathways Inflammatory mediator regulation of TRP channels, Proteoglycans in cancer, Rap1 signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway

PathScan ® Phospho-Src (Tyr416) Sandwich ELISA Kit - 7953 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-Src (Tyr416) Sandwich ELISA Antibody Pair - 7963 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Total Src Sandwich ELISA Antibody Pair - 7992 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)
The relationship between the protein concentration of lysates from untreated and λ-phosphatase-treated Calu-3 cells and the absorbance at 450 nm using the PathScan® Total Src Sandwich ELISA Antibody Pair is shown.

PathScan ® Total Src Sandwich ELISA Kit - 7984 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1. Constitutive phosphorylation of Src at Tyr416 in Calu-3 cells as detected by the PathScan® Phospho-Src (Tyr416) Sandwich ELISA Kit #7953. Treatment of lysate with λ-phosphatase significantly reduces Src phosphorylation but does not alter the levels of total Src protein as detected by the PathScan® Total Src Sandwich ELISA kit #7984. Absorbance at 450 nm is shown in the top figure while the corresponding western blots using Src (L4A1) Mouse mAb #2110 (left) or Phospho-Src Family (Tyr416) (100F9) Rabbit mAb #2113 (right) are shown in the bottom figure.

HTScan® Src Kinase Assay Kit - 7776 from Cell Signaling Technology

Category Assay Kit
Figure 1. Src kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, ATP (variable), 2.5 µg/50 µl PEG20,000, Substrate: PolyEY, 1 µg/50 µl, recombinant Src: 20 ng/50 µl.

Mouse/Human/Rat SRC ELISA Kit (Cell-Based ELISA) - LS-F2322 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human/Rat Phospho-SRC (Tyr418) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1067 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-SRC (Ser75) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1702 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-SRC (Tyr216) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1714 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-SRC (Tyr529) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1621 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Human Phospho-Src (Y419) DuoSet IC ELISA - DYC2685-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)
Range 3.91 - 250 pg/mL

Human Phospho-Src (Y419) DuoSet IC, 5 Plate - DYC2685-5 from R&D Systems

Category ELISA Kit

Proto-oncogene tyrosine-protein kinase Src (SRC), Human, ELISA Kit - CSB-EL022650HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Human Phospho-SRC (Y419) ELISA - PEL-SRC-Y419 from RayBiotech

Category ELISA Kit
Prices $481.00, $866.00, $1,924.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit
PTEN (S380) - Positive Control

Phospho Protein Kinase C, ELISA Kit - MBS032256 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS046592 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS027426 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS081702 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS028459 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS022862 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS024924 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS030556 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS034671 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS032155 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospho Protein Kinase C, ELISA Kit - MBS018079 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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