Gene Symbol | VPS33B |
---|---|
Entrez Gene | 26276 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | vacuolar protein sorting 33 homolog B (yeast) |
Other Description | vacuolar protein sorting-associated protein 33B |
Swissprots | Q96K14 Q9H267 Q9NSF3 Q9NRP6 B3KQF6 |
Accessions | CAF86824 EAX02139 EAX02140 Q9H267 AF201694 AAF91174 AF308803 AAG34680 AJ713428 AK027754 BAB55345 AK074863 BAG52018 AK293688 BAH11570 AK300608 BAH13313 AK308480 AK315721 AL357472 CAB93109 BC016445 AAH16445 CB048637 DA020491 DC397488 XM_005254884 XP_005254941 XM_005254887 XP_005254944 XM_005254888 XP_005254945 XM_011521448 XP_011519750 XM_011521449 XP_011519751 NM_001289148 NP_001276077 NM_001289149 NP_001276078 NM_018668 NP_061138 |
Function | May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. {ECO:0000269|PubMed:18474358}. |
Subcellular Location | Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles. |
Tissue Specificity | Ubiquitous; highly expressed in testis and low expression in the lung. |