Gene Symbol | VPS33B |
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Entrez Gene | 26276 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | vacuolar protein sorting 33 homolog B (yeast) |
Other Description | vacuolar protein sorting-associated protein 33B |
Swissprots | Q96K14 Q9H267 Q9NSF3 Q9NRP6 B3KQF6 |
Accessions | CAF86824 EAX02139 EAX02140 Q9H267 AF201694 AAF91174 AF308803 AAG34680 AJ713428 AK027754 BAB55345 AK074863 BAG52018 AK293688 BAH11570 AK300608 BAH13313 AK308480 AK315721 AL357472 CAB93109 BC016445 AAH16445 CB048637 DA020491 DC397488 XM_005254884 XP_005254941 XM_005254887 XP_005254944 XM_005254888 XP_005254945 XM_011521448 XP_011519750 XM_011521449 XP_011519751 NM_001289148 NP_001276077 NM_001289149 NP_001276078 NM_018668 NP_061138 |
Function | May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. {ECO:0000269|PubMed:18474358}. |
Subcellular Location | Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles. |
Tissue Specificity | Ubiquitous; highly expressed in testis and low expression in the lung. |
VPS33B CRISPR/Cas9 KO Plasmid (h) - sc-406200 from Santa Cruz Biotechnology
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VPS33B HDR Plasmid (h) - sc-406200-HDR from Santa Cruz Biotechnology
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VPS33B Double Nickase Plasmid (h) - sc-406200-NIC from Santa Cruz Biotechnology
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VPS33B Double Nickase Plasmid (h2) - sc-406200-NIC-2 from Santa Cruz Biotechnology
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VPS33B CRISPR Activation Plasmid (h) - sc-406200-ACT from Santa Cruz Biotechnology
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VPS33B CRISPR Activation Plasmid (h2) - sc-406200-ACT-2 from Santa Cruz Biotechnology
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VPS33B Lentiviral Activation Particles (h) - sc-406200-LAC from Santa Cruz Biotechnology
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VPS33B Lentiviral Activation Particles (h2) - sc-406200-LAC-2 from Santa Cruz Biotechnology
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VPS33B siRNA (h) - sc-76905 from Santa Cruz Biotechnology
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VPS33B shRNA Plasmid (h) - sc-76905-SH from Santa Cruz Biotechnology
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VPS33B shRNA (h) Lentiviral Particles - sc-76905-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22718 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22718 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03412 from Sigma-Aldrich
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VPS33B siRNA (Human) - CRH8798 from Cohesion Biosciences
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VPS33B - MBS8218463 from MyBioSource
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shRNA set against Human VPS33B (NM_018668.3) - SHH444940 from Creative biogene
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shRNA set against Human VPS33B(NM_018668.3) - SHL127848 from Creative biogene
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VPS33B shRNA Plasmid (Human) - CHH8798 from Cohesion Biosciences
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VPS33B miRNA 3'UTR clone - MiUTR1H-11152 from Creative biogene
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