| Gene Symbol |
ARHGEF12
|
| Entrez Gene |
23365
|
| Alt Symbol |
LARG, PRO2792
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 12
|
| Other Description |
leukemia-associated RhoGEF|leukemia-associated rho guanine nucleotide exchange factor|rho guanine nucleotide exchange factor 12
|
| Swissprots |
Q9NZN5 O15086 Q6P526
|
| Accessions |
EAW67508 EAW67509 EAW67510 Q9NZN5 AB002380 BAA20836 AF119898 AAF69652 AF180681 AAF36817 AK294803 BAG57923 AK304316 BAG65168 AL137456 BC031784 BC063117 AAH63117 BC152900 AAI52901 BX647785 BX648515 DC350360 XM_005271478 XP_005271535 XM_006718805 XP_006718868 XM_011542720 XP_011541022 NM_001198665 NP_001185594 NM_001301084 NP_001288013 NM_015313 NP_056128
|
| Function |
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Translocated to the membrane upon stimulation. {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
|
| Top Pathways |
Axon guidance, Vascular smooth muscle contraction, Tuberculosis, Proteoglycans in cancer, Regulation of actin cytoskeleton
|
![Western Blot: LARG Lysate [NBL1-07678] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for ARHGEF12](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13650_LARG%2520Lysate-Western%2520Blot-NBL1-07678-img0001.jpg)