ARHGEF12

Gene Symbol	ARHGEF12
Entrez Gene	23365
Alt Symbol	LARG, PRO2792
Species	Human
Gene Type	protein-coding
Description	Rho guanine nucleotide exchange factor (GEF) 12
Other Description	leukemia-associated RhoGEF|leukemia-associated rho guanine nucleotide exchange factor|rho guanine nucleotide exchange factor 12
Swissprots	Q9NZN5 O15086 Q6P526
Accessions	EAW67508 EAW67509 EAW67510 Q9NZN5 AB002380 BAA20836 AF119898 AAF69652 AF180681 AAF36817 AK294803 BAG57923 AK304316 BAG65168 AL137456 BC031784 BC063117 AAH63117 BC152900 AAI52901 BX647785 BX648515 DC350360 XM_005271478 XP_005271535 XM_006718805 XP_006718868 XM_011542720 XP_011541022 NM_001198665 NP_001185594 NM_001301084 NP_001288013 NM_015313 NP_056128
Function	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
Subcellular Location	Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Translocated to the membrane upon stimulation. {ECO:0000305}.
Tissue Specificity	Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
Top Pathways	Axon guidance, Vascular smooth muscle contraction, Tuberculosis, Proteoglycans in cancer, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LARG protein fragment - ab161613 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human LARG Protein - H00023365-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARHGEF12 - H00023365-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ARHGEF12 - H00023365-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LARG fusion protein - ag18321 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LARG fusion protein - Ag18211 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Rho guanine nucleotide exchange factor 12(ARHGEF12) ,partial - CSB-YP868370HU CSB-EP868370HU CSB-BP868370HU CSB-MP868370HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LARG Protein - NBP1-89619PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ARHGEF12 Peptide, Human - M34GP00882H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Rho Guanine Nucleotide Exchange Factor 12 (ARHGEF12), transfected HEK293 cell lysate - 230-10176-100 from RayBiotech Category Protein Prices $135.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human Rho Guanine Nucleotide Exchange Factor 12 (ARHGEF12), transfected HEK293 cell culture supernatant - 230-20143-200 from RayBiotech Category Protein Prices $110.00 Sizes 200 µl Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Human ARHGEF12, transfected HEK293 cell Lysate - orb385173 from Biorbyt Category Protein Prices $349.00 Sizes 100 μg Species Human

Human ARHGEF12 protein - orb385242 from Biorbyt Category Protein Prices $306.00 Sizes 200 μg Species Human

Rho guanine nucleotide exchange factor 12 (ARHGEF12), partial, Recombinant Protein - MBS1279861 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more