TOP1

Gene Symbol	TOP1
Entrez Gene	7150
Alt Symbol	TOPI
Species	Human
Gene Type	protein-coding
Description	topoisomerase (DNA) I
Other Description	DNA topoisomerase 1|type I DNA topoisomerase
Swissprots	E1P5W3 O43256 A8KA78 Q9UJN0 Q12856 Q12855 Q15610 P11387 Q5TFY3
Accessions	AAA61206 CAA36834 EAW75994 EAW75995 EAW75996 EAW75997 P11387 AK225095 AK292943 BAF85632 AK310508 AK310516 BC000943 AAH00943 BC004475 AAH04475 BC039009 BC056681 BC067349 AAH67349 BC136297 AAI36298 J03250 AAA61207 M27913 AAA61208 U07804 AAB60379 U07806 AAB60380 X16479 CAA34500 XM_011529032 XP_011527334 XM_011529033 XP_011527335 NM_003286 NP_003277
Function	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:12149243}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12149243}. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.
Tissue Specificity	Endothelial cells. {ECO:0000269|PubMed:19168442}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TOP1 / Topoisomerase I ELISA Kit (Sandwich ELISA) - LS-F6459 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse TOP1 / Topoisomerase I ELISA Kit (Sandwich ELISA) - LS-F9083 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Mouse TOP1 / Topoisomerase I ELISA Kit (Sandwich ELISA) - LS-F12828 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human TOP1 / Topoisomerase I ELISA Kit (Sandwich ELISA) - LS-F12829 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 ng/ml Range 0.156-10 ng/ml

Human DNA topoisomerase 1 ELISA Kit - abx052815 from Abbexa Category ELISA Kit

DNA topoisomerase 1 (TOP1), Human, ELISA Kit - CSB-EL024056HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

DNA topoisomerase 1, TOP1, Human, ELISA Kit - E9586h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 1.56-100 ng/mL

Topoisomerase I (TOP1), Human, ELISA Kit - SEC243Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.104ng/mL Range 0.312-20ng/mL

DNA topoisomerase 1 (TOP1) autoantibody, ELISA Kit - MBS9310889 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

topoisomerase (DNA) I, ELISA Kit - MBS927247 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Topoisomerase I (TOP1) - SEC243Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Topoisomerase I (TOP1) - SEC243Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human DNA topoisomerase 1(TOP1) ELISA kit - CSB-EL024056HU from Cusabio Category ELISA Kit Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

ELISA Kit for Topoisomerase I (TOP1) - SEC243Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat TOP1 / Topoisomerase I ELISA Kit (Custom ELISA) - LS-F20486 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human DNA topoisomerase 1 ELISA Kit - abx251860 from Abbexa Category ELISA Kit Range 1.56 ng/ml - 100 ng/ml

ELISA Kit for Topoisomerase I (TOP1) - SEC243Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Topoisomerase I (TOP1), Human, ELISA Kit - DL-TOP1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human TOP1 ELISA Kit - orb367881 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 1.563-100ng/mL Detection low threshold: 0.60ng/mL

Human TOP1 ELISA Kit - abx573911 from Abbexa Category ELISA Kit Sensitivity 0.60 ng/ml Range 1.563 ng/ml - 100 ng/ml

Human DNA topoisomerase 1(TOP1) ELISA Kit - EKC33488 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity Request Information Range Request Information

Human DNA topoisomerase 1 ELISA Kit - EKE54875 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.67 ng/mL Range 1.56-100 ng/mL

TOP1 - EKH4982 from Nordic BioSite Sensitivity 0.938ng/ml Range 1.56-100ng/ml

TOP1 ELISA Kit (Human) : 96 Wells (OKEH01982) - OKEH01982 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.67 ng/mL Range 1.56 - 100 ng/mL

Human TOP1 ELISA Kit - E012169 from Biobool Category ELISA Kit

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