| Gene Symbol |
MUC12
|
| Entrez Gene |
10071
|
| Alt Symbol |
MUC-11, MUC-12, MUC11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mucin 12, cell surface associated
|
| Other Description |
mucin 11|mucin-11|mucin-12
|
| Swissprots |
Q9UKN0 A6ND38 F5GWV9 Q9UKN1
|
| Accessions |
CCQ42956 EAW50190 Q9UKN1 AF147790 AAD55678 AF147791 AAD55679 AK024856 AK025404 AK296627 BAH12403 BC127877 AAI27878 NM_001164462 NP_001157934
|
| Function |
Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn's disease (CD). {ECO:0000269|PubMed:10463611, ECO:0000269|PubMed:17058067}.
|