Gene Symbol | MUC12 |
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Entrez Gene | 10071 |
Alt Symbol | MUC-11, MUC-12, MUC11 |
Species | Human |
Gene Type | protein-coding |
Description | mucin 12, cell surface associated |
Other Description | mucin 11|mucin-11|mucin-12 |
Swissprots | Q9UKN0 A6ND38 F5GWV9 Q9UKN1 |
Accessions | CCQ42956 EAW50190 Q9UKN1 AF147790 AAD55678 AF147791 AAD55679 AK024856 AK025404 AK296627 BAH12403 BC127877 AAI27878 NM_001164462 NP_001157934 |
Function | Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn's disease (CD). {ECO:0000269|PubMed:10463611, ECO:0000269|PubMed:17058067}. |
Mucin 12 CRISPR/Cas9 KO Plasmid (h) - sc-400505 from Santa Cruz Biotechnology
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Mucin 12 HDR Plasmid (h) - sc-400505-HDR from Santa Cruz Biotechnology
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Mucin 12 Double Nickase Plasmid (h) - sc-400505-NIC from Santa Cruz Biotechnology
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Mucin 12 Double Nickase Plasmid (h2) - sc-400505-NIC-2 from Santa Cruz Biotechnology
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Mucin 12 CRISPR Activation Plasmid (h) - sc-400505-ACT from Santa Cruz Biotechnology
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Mucin 12 CRISPR Activation Plasmid (h2) - sc-400505-ACT-2 from Santa Cruz Biotechnology
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Mucin 12 Lentiviral Activation Particles (h) - sc-400505-LAC from Santa Cruz Biotechnology
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Mucin 12 Lentiviral Activation Particles (h2) - sc-400505-LAC-2 from Santa Cruz Biotechnology
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Mucin 12 siRNA (h) - sc-45683 from Santa Cruz Biotechnology
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Mucin 12 shRNA Plasmid (h) - sc-45683-SH from Santa Cruz Biotechnology
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Mucin 12 shRNA (h) Lentiviral Particles - sc-45683-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN14751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14751 from Sigma-Aldrich
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shRNA set against Human MUC12 (NM_001164462.1) - SHH346832 from Creative biogene
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