| Gene Symbol |
Dnmt3l
|
| Entrez Gene |
54427
|
| Alt Symbol |
D6Ertd14e, ecat7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
DNA (cytosine-5-)-methyltransferase 3-like
|
| Other Description |
DNA (cytosine-5)-methyltransferase 3-like
|
| Swissprots |
Q9CWR8
|
| Accessions |
EDL31748 EDL31749 Q9CWR8 AF220524 AAF73868 AJ404467 CAB94726 AK010434 BAB26936 AV473569 AV511576 BC083147 AAH83147 EF051621 EF051622 EF051623 EF051624 ABN46989 XM_011243514 XP_011241816 NM_001081695 NP_001075164 NM_001284197 NP_001271126 NM_001284198 NP_001271127 NM_001284199 NP_001271128 NM_001284200 NP_001271129 NM_019448 NP_062321
|
| Function |
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. {ECO:0000269|PubMed:11719692, ECO:0000269|PubMed:15671018}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in testis, thymus, ovary, and heart.
|