Gene Symbol | Dnmt3l |
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Entrez Gene | 54427 |
Alt Symbol | D6Ertd14e, ecat7 |
Species | Mouse |
Gene Type | protein-coding |
Description | DNA (cytosine-5-)-methyltransferase 3-like |
Other Description | DNA (cytosine-5)-methyltransferase 3-like |
Swissprots | Q9CWR8 |
Accessions | EDL31748 EDL31749 Q9CWR8 AF220524 AAF73868 AJ404467 CAB94726 AK010434 BAB26936 AV473569 AV511576 BC083147 AAH83147 EF051621 EF051622 EF051623 EF051624 ABN46989 XM_011243514 XP_011241816 NM_001081695 NP_001075164 NM_001284197 NP_001271126 NM_001284198 NP_001271127 NM_001284199 NP_001271128 NM_001284200 NP_001271129 NM_019448 NP_062321 |
Function | Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. {ECO:0000269|PubMed:11719692, ECO:0000269|PubMed:15671018}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed in testis, thymus, ovary, and heart. |
SignalSilence ® DNMT3L siRNA II (Mouse Specific) - 12308 from Cell Signaling Technology
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SignalSilence ® DNMT3L siRNA I (Mouse Specific) - 12307 from Cell Signaling Technology
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Dnmt3L CRISPR/Cas9 KO Plasmid (m) - sc-424871 from Santa Cruz Biotechnology
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Dnmt3L HDR Plasmid (m) - sc-424871-HDR from Santa Cruz Biotechnology
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Dnmt3L Double Nickase Plasmid (m) - sc-424871-NIC from Santa Cruz Biotechnology
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Dnmt3L Double Nickase Plasmid (m2) - sc-424871-NIC-2 from Santa Cruz Biotechnology
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Dnmt3L CRISPR Activation Plasmid (m) - sc-424871-ACT from Santa Cruz Biotechnology
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Dnmt3L CRISPR Activation Plasmid (m2) - sc-424871-ACT-2 from Santa Cruz Biotechnology
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Dnmt3L Lentiviral Activation Particles (m) - sc-424871-LAC from Santa Cruz Biotechnology
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Dnmt3L Lentiviral Activation Particles (m2) - sc-424871-LAC-2 from Santa Cruz Biotechnology
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Dnmt3L siRNA (m) - sc-37762 from Santa Cruz Biotechnology
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Dnmt3L shRNA Plasmid (m) - sc-37762-SH from Santa Cruz Biotechnology
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Dnmt3L shRNA (m) Lentiviral Particles - sc-37762-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU022701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30149 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30149 from Sigma-Aldrich
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DNMT3L siRNA (Mouse) - CRM5524 from Cohesion Biosciences
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DNMT3L - MBS8202980 from MyBioSource
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shRNA set against Mouse DNMT3L (NM_019448.3) - SHH280041 from Creative biogene
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shRNA set against Mouse Dnmt3l(NM_019448.3) - SHH012701 from Creative biogene
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shRNA set against Mouse Dnmt3l(NM_001081695.1) - SHH012737 from Creative biogene
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Mouse DNMT3L siRNA - orb285000 from Biorbyt
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DNMT3L shRNA Plasmid (Mouse) - CHM5524 from Cohesion Biosciences
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DNMT3L miRNA 3'UTR clone - MiUTR1M-03944 from Creative biogene
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DNMT3L miRNA 3'UTR clone - MiUTR1M-03945 from Creative biogene
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