| Gene Symbol |
HS3ST2
|
| Entrez Gene |
9956
|
| Alt Symbol |
30ST2, 3OST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
|
| Other Description |
3-OST-2|h3-OST-2|heparan sulfate 3-O-sulfotransferase 2|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2|heparan sulfate glucosamine 3-O-sulfotransferase 2|heparin-glucosamine 3-O-sulfotransferase
|
| Swissprots |
Q52LZ1 Q9Y278
|
| Accessions |
EAW55840 Q9Y278 AB209794 BAD93031 AF105374 AAD30206 AF105375 AAD30207 AK313463 BAG36249 AY359095 AAQ89453 BC093734 AAH93734 BC093736 AAH93736 XM_011546001 XP_011544303 XM_011546002 XP_011544304 NM_006043 NP_006034
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle. {ECO:0000269|PubMed:9988767}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
