Gene Symbol | HS3ST2 |
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Entrez Gene | 9956 |
Alt Symbol | 30ST2, 3OST2 |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
Other Description | 3-OST-2|h3-OST-2|heparan sulfate 3-O-sulfotransferase 2|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2|heparan sulfate glucosamine 3-O-sulfotransferase 2|heparin-glucosamine 3-O-sulfotransferase |
Swissprots | Q52LZ1 Q9Y278 |
Accessions | EAW55840 Q9Y278 AB209794 BAD93031 AF105374 AAD30206 AF105375 AAD30207 AK313463 BAG36249 AY359095 AAQ89453 BC093734 AAH93734 BC093736 AAH93736 XM_011546001 XP_011544303 XM_011546002 XP_011544304 NM_006043 NP_006034 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle. {ECO:0000269|PubMed:9988767}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
HS3ST2 CRISPR/Cas9 KO Plasmid (h) - sc-409766 from Santa Cruz Biotechnology
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HS3ST2 HDR Plasmid (h) - sc-409766-HDR from Santa Cruz Biotechnology
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HS3ST2 Double Nickase Plasmid (h) - sc-409766-NIC from Santa Cruz Biotechnology
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HS3ST2 Double Nickase Plasmid (h2) - sc-409766-NIC-2 from Santa Cruz Biotechnology
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HS3ST2 CRISPR Activation Plasmid (h) - sc-409766-ACT from Santa Cruz Biotechnology
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HS3ST2 CRISPR Activation Plasmid (h2) - sc-409766-ACT-2 from Santa Cruz Biotechnology
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HS3ST2 Lentiviral Activation Particles (h) - sc-409766-LAC from Santa Cruz Biotechnology
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HS3ST2 Lentiviral Activation Particles (h2) - sc-409766-LAC-2 from Santa Cruz Biotechnology
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HS3ST2 siRNA (h) - sc-93072 from Santa Cruz Biotechnology
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HS3ST2 shRNA Plasmid (h) - sc-93072-SH from Santa Cruz Biotechnology
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HS3ST2 shRNA (h) Lentiviral Particles - sc-93072-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU019951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10307 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10307 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06977 from Sigma-Aldrich
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HS3ST2 siRNA (Human) - CRH6695 from Cohesion Biosciences
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HS3ST2 RNAi - H00009956-R01 from Novus Biologicals
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HS3ST2 - MBS8221380 from MyBioSource
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shRNA set against Human HS3ST2 (NM_006043.1) - SHH314969 from Creative biogene
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shRNA set against Human HS3ST2(NM_006043.1) - SHH131699 from Creative biogene
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Human HS3ST2 siRNA - orb267197 from Biorbyt
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HS3ST2 shRNA Plasmid (Human) - CHH6695 from Cohesion Biosciences
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HS3ST2 miRNA 3'UTR clone - MiUTR1H-04702 from Creative biogene
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