| Gene Symbol |
CMPK1
|
| Entrez Gene |
51727
|
| Alt Symbol |
CK, CMK, CMPK, UMK, UMP-CMPK, UMPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
|
| Other Description |
CK|UMP-CMP kinase|UMP/CMP kinase|cytidylate kinase|dCMP kinase|deoxycytidylate kinase|nucleoside-diphosphate kinase|uridine monophosphate kinase|uridine monophosphate/cytidine monophosphate kinase
|
| Swissprots |
B4DPU7 Q5SVZ0 E9PGI8 Q9UIA2 Q53GB7 P30085 Q9UBQ8 Q96C07
|
| Accessions |
EAX06869 EAX06870 EAX06871 P30085 AF070416 AAF17709 AF087865 AAP97174 AF110643 AAD48583 AF112216 AAF17204 AF259961 AAG22609 AK025258 AK027204 AK223014 BAD96734 AK293238 BAG56775 AK294294 BAG57577 AK298502 BAG60709 AK312693 BAG35572 BC014961 AAH14961 BC017806 DB494965 DQ892213 ABM83139 DQ895408 ABM86334 DQ895409 ABM86335 NM_001136140 NP_001129612 NM_016308 NP_057392 NR_046394 NR_046395
|
| Function |
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly nuclear.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11681623}.
|
| Top Pathways |
Pyrimidine metabolism
|
