Gene Symbol | CMPK1 |
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Entrez Gene | 51727 |
Alt Symbol | CK, CMK, CMPK, UMK, UMP-CMPK, UMPK |
Species | Human |
Gene Type | protein-coding |
Description | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic |
Other Description | CK|UMP-CMP kinase|UMP/CMP kinase|cytidylate kinase|dCMP kinase|deoxycytidylate kinase|nucleoside-diphosphate kinase|uridine monophosphate kinase|uridine monophosphate/cytidine monophosphate kinase |
Swissprots | B4DPU7 Q5SVZ0 E9PGI8 Q9UIA2 Q53GB7 P30085 Q9UBQ8 Q96C07 |
Accessions | EAX06869 EAX06870 EAX06871 P30085 AF070416 AAF17709 AF087865 AAP97174 AF110643 AAD48583 AF112216 AAF17204 AF259961 AAG22609 AK025258 AK027204 AK223014 BAD96734 AK293238 BAG56775 AK294294 BAG57577 AK298502 BAG60709 AK312693 BAG35572 BC014961 AAH14961 BC017806 DB494965 DQ892213 ABM83139 DQ895408 ABM86334 DQ895409 ABM86335 NM_001136140 NP_001129612 NM_016308 NP_057392 NR_046394 NR_046395 |
Function | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11681623}. |
Top Pathways | Pyrimidine metabolism |
CMPK CRISPR/Cas9 KO Plasmid (h) - sc-405332 from Santa Cruz Biotechnology
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CMPK HDR Plasmid (h) - sc-405332-HDR from Santa Cruz Biotechnology
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CMPK Double Nickase Plasmid (h) - sc-405332-NIC from Santa Cruz Biotechnology
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CMPK Double Nickase Plasmid (h2) - sc-405332-NIC-2 from Santa Cruz Biotechnology
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CMPK CRISPR Activation Plasmid (h) - sc-405332-ACT from Santa Cruz Biotechnology
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CMPK CRISPR Activation Plasmid (h2) - sc-405332-ACT-2 from Santa Cruz Biotechnology
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CMPK Lentiviral Activation Particles (h) - sc-405332-LAC from Santa Cruz Biotechnology
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CMPK Lentiviral Activation Particles (h2) - sc-405332-LAC-2 from Santa Cruz Biotechnology
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CMPK siRNA (h) - sc-88593 from Santa Cruz Biotechnology
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CMPK shRNA Plasmid (h) - sc-88593-SH from Santa Cruz Biotechnology
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CMPK shRNA (h) Lentiviral Particles - sc-88593-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU005081 from Sigma-Aldrich
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MISSION® siRNA - SIHK0470 from Sigma-Aldrich
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MISSION® siRNA - SIHK0471 from Sigma-Aldrich
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MISSION® siRNA - SIHK0472 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6285 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6285 from Sigma-Aldrich
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CMPK1 siRNA (Human) - CRH9920 from Cohesion Biosciences
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CMP kinase RNAi - H00051727-R02 from Novus Biologicals
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CMPK1 - MBS8203659 from MyBioSource
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shRNA set against Human CMPK1 (NM_016308.2) - SHH265957 from Creative biogene
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Human CMPK1 siRNA - orb270422 from Biorbyt
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CMPK1 shRNA Plasmid (Human) - CHH9920 from Cohesion Biosciences
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CMPK1 miRNA 3'UTR clone - MiUTR4H-TG02202 from Creative biogene
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