| Gene Symbol |
G6PC2
|
| Entrez Gene |
57818
|
| Alt Symbol |
IGRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucose-6-phosphatase, catalytic, 2
|
| Other Description |
G-6-Pase 2|G6Pase 2|glucose-6-phosphatase 2|islet-specific G6CP-related protein|islet-specific glucose-6-phosphatase catalytic subunit-related protein|islet-specific glucose-6-phosphatase-related protein
|
| Swissprots |
Q6AHZ0 Q9NQR9 E9PAX2
|
| Accessions |
AAF82810 AAY24099 EAX11291 Q9NQR9 AK310853 BC104778 AAI04779 BC113376 AAI13377 BQ268961 CA865646 CR627438 CAH10524 HQ258182 ADR82936 XM_011511564 XP_011509866 XM_011511565 XP_011509867 XM_011546941 XP_011545243 XM_011546942 XP_011545244 NM_001081686 NP_001075155 NM_021176 NP_066999
|
| Function |
May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044018}; Multi-pass membrane protein {ECO:0000269|PubMed:15044018}.
|
| Tissue Specificity |
Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level). {ECO:0000269|PubMed:11297555}.
|
| Top Pathways |
Glucagon signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, Carbohydrate digestion and absorption, Glycolysis / Gluconeogenesis
|
![Western Blot: G6PC2 Overexpression Lysate (Adult Normal) [NBL1-10897] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for G6PC2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26172_G6PC2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10897-img0002.jpg)