| Gene Symbol |
CHSY3
|
| Entrez Gene |
337876
|
| Alt Symbol |
CHSY2, CSS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chondroitin sulfate synthase 3
|
| Other Description |
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3|N-acetylgalactosaminyltransferase 3|carbohydrate synthase 2|chSy-2|chondroitin glucuronyltransferase 3|chondroitin synthase 2|chondroitin synthase-2|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
|
| Swissprots |
Q76L22 Q86Y52 B2RP97 Q70JA7
|
| Accessions |
EAW62379 Q70JA7 AB086062 BAC98832 AB175496 BAF47165 AJ504664 CAD43233 AJ578034 CAE17326 AJ632296 CAG17593 AJ862728 CAH89316 AY726604 BC137325 AAI37326 XM_005271982 XP_005272039 XM_005271983 XP_005272040 XM_011543363 XP_011541665 XM_011543364 XP_011541666 XM_011543365 XP_011541667 NM_175856 NP_787052
|
| Function |
Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269|PubMed:12907687}.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:12907687}; Single-pass type II membrane protein {ECO:0000305|PubMed:12907687}.
|
| Tissue Specificity |
Detected at low levels in brain, cerebral cortex, uterus and small intestine. {ECO:0000269|PubMed:12907687}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|