Gene Symbol | CHSY3 |
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Entrez Gene | 337876 |
Alt Symbol | CHSY2, CSS3 |
Species | Human |
Gene Type | protein-coding |
Description | chondroitin sulfate synthase 3 |
Other Description | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3|N-acetylgalactosaminyltransferase 3|carbohydrate synthase 2|chSy-2|chondroitin glucuronyltransferase 3|chondroitin synthase 2|chondroitin synthase-2|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II |
Swissprots | Q76L22 Q86Y52 B2RP97 Q70JA7 |
Accessions | EAW62379 Q70JA7 AB086062 BAC98832 AB175496 BAF47165 AJ504664 CAD43233 AJ578034 CAE17326 AJ632296 CAG17593 AJ862728 CAH89316 AY726604 BC137325 AAI37326 XM_005271982 XP_005272039 XM_005271983 XP_005272040 XM_011543363 XP_011541665 XM_011543364 XP_011541666 XM_011543365 XP_011541667 NM_175856 NP_787052 |
Function | Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269|PubMed:12907687}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:12907687}; Single-pass type II membrane protein {ECO:0000305|PubMed:12907687}. |
Tissue Specificity | Detected at low levels in brain, cerebral cortex, uterus and small intestine. {ECO:0000269|PubMed:12907687}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
CHSY3 CRISPR/Cas9 KO Plasmid (h) - sc-409092 from Santa Cruz Biotechnology
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CHSY3 HDR Plasmid (h) - sc-409092-HDR from Santa Cruz Biotechnology
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CHSY3 Double Nickase Plasmid (h) - sc-409092-NIC from Santa Cruz Biotechnology
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CHSY3 Double Nickase Plasmid (h2) - sc-409092-NIC-2 from Santa Cruz Biotechnology
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CHSY3 CRISPR Activation Plasmid (h) - sc-409092-ACT from Santa Cruz Biotechnology
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CHSY3 CRISPR Activation Plasmid (h2) - sc-409092-ACT-2 from Santa Cruz Biotechnology
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CHSY3 Lentiviral Activation Particles (h) - sc-409092-LAC from Santa Cruz Biotechnology
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CHSY3 Lentiviral Activation Particles (h2) - sc-409092-LAC-2 from Santa Cruz Biotechnology
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CHSY3 siRNA (h) - sc-60383 from Santa Cruz Biotechnology
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CHSY3 shRNA Plasmid (h) - sc-60383-SH from Santa Cruz Biotechnology
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CHSY3 shRNA (h) Lentiviral Particles - sc-60383-V from Santa Cruz Biotechnology
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Chondroitin sulfate synthase 3 RNAi - H00337876-R01 from Novus Biologicals
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MISSION® esiRNA - EHU101931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6119 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6119 from Sigma-Aldrich
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CHSY3 siRNA (Human) - CRJ7207 from Cohesion Biosciences
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CHSY3 - MBS8208123 from MyBioSource
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shRNA set against Human CHSY3 (NM_175856.4) - SHH263889 from Creative biogene
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CHSY3 shRNA Plasmid (Human) - CHJ7207 from Cohesion Biosciences
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CHSY3 miRNA 3'UTR clone - MiUTR1H-02154 from Creative biogene
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