| Gene Symbol |
ANO3
|
| Entrez Gene |
63982
|
| Alt Symbol |
C11orf25, DYT23, DYT24, GENX-3947, TMEM16C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anoctamin 3
|
| Other Description |
anoctamin-3|transmembrane protein 16C (eight membrane-spanning domains)
|
| Swissprots |
Q9BYT9 B7Z3F5
|
| Accessions |
EAW68296 Q9BYT9 AJ300461 CAC32454 AK295143 BAH11989 AK295658 BAH12144 AK295816 BAH12191 AK302659 BAH13772 AK304781 BAH14255 AK316018 BAH14389 BC172396 AAI72396 BQ430769 DA247850 HG503613 X81896 XM_011520282 XP_011518584 XM_011520283 XP_011518585 NM_031418 NP_113606
|
| Function |
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000250|UniProtKB:A2AHL1, ECO:0000269|PubMed:21984732}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Shows an intracellular localization. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in the forebrain striatum. {ECO:0000269|PubMed:23200863}.
|