Gene Symbol | ANO3 |
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Entrez Gene | 63982 |
Alt Symbol | C11orf25, DYT23, DYT24, GENX-3947, TMEM16C |
Species | Human |
Gene Type | protein-coding |
Description | anoctamin 3 |
Other Description | anoctamin-3|transmembrane protein 16C (eight membrane-spanning domains) |
Swissprots | Q9BYT9 B7Z3F5 |
Accessions | EAW68296 Q9BYT9 AJ300461 CAC32454 AK295143 BAH11989 AK295658 BAH12144 AK295816 BAH12191 AK302659 BAH13772 AK304781 BAH14255 AK316018 BAH14389 BC172396 AAI72396 BQ430769 DA247850 HG503613 X81896 XM_011520282 XP_011518584 XM_011520283 XP_011518585 NM_031418 NP_113606 |
Function | Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000250|UniProtKB:A2AHL1, ECO:0000269|PubMed:21984732}. |
Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Shows an intracellular localization. {ECO:0000250}. |
Tissue Specificity | Highly expressed in the forebrain striatum. {ECO:0000269|PubMed:23200863}. |
TMEM16C (C-15) - sc-244372 from Santa Cruz Biotechnology
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TMEM16C (N-20) - sc-244370 from Santa Cruz Biotechnology
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Anti-Anoctamin 3 antibody - ab82781 from Abcam
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Anti-ANO3 / TMEM16C Antibody (aa828-877) - LS-C81498 from LifeSpan Bioscience
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Anti-ANO3 / TMEM16C Antibody (aa719-768) - LS-C107969 from LifeSpan Bioscience
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ANO3 Antibody - NBP1-88546 from Novus Biologicals
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ANO3 Antibody - NBP1-70410 from Novus Biologicals
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ANO3 Antibody - NBP1-70409 from Novus Biologicals
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TMEM16C/Anoctamin 3 Polyclonal Antibody - bs-12479R from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12479R-A350 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12479R-A488 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12479R-A555 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12479R-A647 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, Cy3 Conjugated - bs-12479R-Cy3 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, Cy5 Conjugated - bs-12479R-Cy5 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, Cy5.5 Conjugated - bs-12479R-Cy5.5 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, Cy7 Conjugated - bs-12479R-Cy7 from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, FITC Conjugated - bs-12479R-FITC from Bioss
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Rabbit Anti-TMEM16C/Anoctamin 3 Polyclonal Antibody, PE Conjugated - bs-12479R-PE from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, Biotin Conjugated - bs-12479R-Biotin from Bioss
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TMEM16C/Anoctamin 3 Polyclonal Antibody, HRP Conjugated - bs-12479R-HRP from Bioss
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Anti-ANO3 antibody produced in rabbit - HPA041629 from Sigma-Aldrich
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Anti-TMEM16C antibody produced in rabbit - SAB2105171 from Sigma-Aldrich
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Anti-TMEM16C antibody produced in rabbit - SAB2102461 from Sigma-Aldrich
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TMEM16C antibody - middle region (ARP49996_P050) - ARP49996_P050 from Aviva Systems Biology
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