| Gene Symbol |
ABCC11
|
| Entrez Gene |
85320
|
| Alt Symbol |
EWWD, MRP8, WW
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
|
| Other Description |
ATP-binding cassette protein C11|ATP-binding cassette sub-family C member 11|ATP-binding cassette transporter MRP8|ATP-binding cassette transporter sub-family C member 11|multi-resistance protein 8|multidrug resistance-associated protein 8
|
| Swissprots |
Q9BX80 Q96JA6 Q96J66 Q8TDJ0
|
| Accessions |
EAW82715 EAW82716 EAW82717 EAW82718 EAW82719 EAW82720 EAW82721 EAW82722 Q96J66 AF352582 AAK19755 AF367202 AAK58869 AF411579 AAL99902 AK301547 BAG63044 AL117406 AY040219 AAK76739 BC039085 BC152902 AAI52903 BC157084 AAI57085 XM_011523396 XP_011521698 XM_011523397 XP_011521699 XM_011523398 XP_011521700 NM_032583 NP_115972 NM_033151 NP_149163 NM_145186 NP_660187
|
| Function |
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. {ECO:0000269|PubMed:11483364, ECO:0000269|PubMed:11591886}.
|
| Top Pathways |
ABC transporters
|