ABCC11
| Gene Symbol | ABCC11 |
|---|---|
| Entrez Gene | 85320 |
| Alt Symbol | EWWD, MRP8, WW |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 |
| Other Description | ATP-binding cassette protein C11|ATP-binding cassette sub-family C member 11|ATP-binding cassette transporter MRP8|ATP-binding cassette transporter sub-family C member 11|multi-resistance protein 8|multidrug resistance-associated protein 8 |
| Swissprots | Q9BX80 Q96JA6 Q96J66 Q8TDJ0 |
| Accessions | EAW82715 EAW82716 EAW82717 EAW82718 EAW82719 EAW82720 EAW82721 EAW82722 Q96J66 AF352582 AAK19755 AF367202 AAK58869 AF411579 AAL99902 AK301547 BAG63044 AL117406 AY040219 AAK76739 BC039085 BC152902 AAI52903 BC157084 AAI57085 XM_011523396 XP_011521698 XM_011523397 XP_011521699 XM_011523398 XP_011521700 NM_032583 NP_115972 NM_033151 NP_149163 NM_145186 NP_660187 |
| Function | Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. {ECO:0000269|PubMed:11483364, ECO:0000269|PubMed:11591886}. |
| Top Pathways | ABC transporters |
ABCC11 CRISPR/Cas9 KO Plasmid (h) - sc-406425 from Santa Cruz Biotechnology
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ABCC11 HDR Plasmid (h) - sc-406425-HDR from Santa Cruz Biotechnology
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ABCC11 Double Nickase Plasmid (h) - sc-406425-NIC from Santa Cruz Biotechnology
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ABCC11 Double Nickase Plasmid (h2) - sc-406425-NIC-2 from Santa Cruz Biotechnology
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ABCC11 CRISPR Activation Plasmid (h) - sc-406425-ACT from Santa Cruz Biotechnology
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ABCC11 CRISPR Activation Plasmid (h2) - sc-406425-ACT-2 from Santa Cruz Biotechnology
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ABCC11 Lentiviral Activation Particles (h) - sc-406425-LAC from Santa Cruz Biotechnology
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ABCC11 Lentiviral Activation Particles (h2) - sc-406425-LAC-2 from Santa Cruz Biotechnology
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ABCC11 siRNA (h) - sc-43594 from Santa Cruz Biotechnology
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ABCC11 shRNA Plasmid (h) - sc-43594-SH from Santa Cruz Biotechnology
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ABCC11 shRNA (h) Lentiviral Particles - sc-43594-V from Santa Cruz Biotechnology
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ABCC11 RNAi - H00085320-R05 from Novus Biologicals
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ABCC11 RNAi - H00085320-R06 from Novus Biologicals
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ABCC11 RNAi - H00085320-R04 from Novus Biologicals
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MISSION® esiRNA - EHU065841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2514 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2514 from Sigma-Aldrich
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ABCC11 siRNA (Human) - CRJ3780 from Cohesion Biosciences
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ABCC11 - MBS8210686 from MyBioSource
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shRNA set against Human ABCC11 (NM_032583.3) - SHH229094 from Creative biogene
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shRNA set against Human ABCC11(NM_145186.2) - SHG023905 from Creative biogene
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Human ABCC11 siRNA - orb274281 from Biorbyt
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ABCC11 shRNA Plasmid (Human) - CHJ3780 from Cohesion Biosciences
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ABCC11 miRNA 3'UTR clone - MiUTR1H-00037 from Creative biogene
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ABCC11 miRNA 3'UTR clone - MiUTR1H-00038 from Creative biogene
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