ABCC11

Gene Symbol	ABCC11
Entrez Gene	85320
Alt Symbol	EWWD, MRP8, WW
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Other Description	ATP-binding cassette protein C11|ATP-binding cassette sub-family C member 11|ATP-binding cassette transporter MRP8|ATP-binding cassette transporter sub-family C member 11|multi-resistance protein 8|multidrug resistance-associated protein 8
Swissprots	Q9BX80 Q96JA6 Q96J66 Q8TDJ0
Accessions	EAW82715 EAW82716 EAW82717 EAW82718 EAW82719 EAW82720 EAW82721 EAW82722 Q96J66 AF352582 AAK19755 AF367202 AAK58869 AF411579 AAL99902 AK301547 BAG63044 AL117406 AY040219 AAK76739 BC039085 BC152902 AAI52903 BC157084 AAI57085 XM_011523396 XP_011521698 XM_011523397 XP_011521699 XM_011523398 XP_011521700 NM_032583 NP_115972 NM_033151 NP_149163 NM_145186 NP_660187
Function	Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. {ECO:0000269|PubMed:11483364, ECO:0000269|PubMed:11591886}.
Top Pathways	ABC transporters

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ABCC11 (H-215) - sc-20969 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ABCC11 (S-19) - sc-249895 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ABCC11 antibody - ab186228 from Abcam Host Rabbit Clonality Polyclonal

Anti-ABCC11 antibody - ab76727 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ABCC11 antibody - ab82152 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-ABCC11 antibody [M8I-74] - ab91452 from Abcam Prices $378.00 Sizes 500 µl Host Rat Clonality Monoclonal Clone M8I-74

Anti-ABCC11 / MRP8 Antibody (aa1-83, clone M8I-74) - LS-C124159 from LifeSpan Bioscience Prices $635.00 Sizes 1 ml Host Rat Clonality Monoclonal Clone M8I-74

Anti-ABCC11 / MRP8 Antibody (clone M8I-74) - LS-C146611 from LifeSpan Bioscience Prices $325.00 Sizes 1 ml Host Rat Clonality Monoclonal Clone M8I-74

Anti-ABCC11 / MRP8 Antibody (aa343-372, AP) - LS-C232298 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa343-372, Biotin) - LS-C232299 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa343-372, PE) - LS-C232304 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa343-372, FITC) - LS-C232301 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa343-372, APC) - LS-C232300 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa343-372, Azide-free, HRP) - LS-C249351 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody - LS-C306020 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody - LS-C309279 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa1295-1344) - LS-C110811 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa433-533) - LS-C306021 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ABCC11 / MRP8 Antibody (aa350-380) - LS-C319238 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody - LS-C340949 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-S100A8 / MRP8 Antibody - LS-C175903 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa343-372) - LS-C155845 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ABCC11 / MRP8 Antibody (aa1352-1364) IHC-plus™ - LS-B9198 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

ABCC11 Antibody - NBP1-82623 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ABCC11 Antibody - NBP1-59810 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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