| Gene Symbol |
ICT1
|
| Entrez Gene |
3396
|
| Alt Symbol |
DS-1, DS1, MRP-L58
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
immature colon carcinoma transcript 1
|
| Other Description |
39S ribosomal protein L58, mitochondrial|digestion substraction 1|immature colon carcinoma transcript 1 protein|peptidyl-tRNA hydrolase ICT1, mitochondrial
|
| Swissprots |
Q53HM7 Q53Y11 B2RAD1 Q14197
|
| Accessions |
EAW89227 Q14197 AK222553 BAD96273 AK314138 BAG36828 BC015335 AAH15335 BI870683 BT007111 AAP35775 DB456649 DQ890655 ABM81581 DQ893834 ABM84760 X81788 CAA57387 NM_001303265 NP_001290194 NM_001545 NP_001536
|
| Function |
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. {ECO:0000269|PubMed:20186120}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:23908630}.
|
| Tissue Specificity |
Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells. {ECO:0000269|PubMed:8575443}.
|
![Western Blot: ICT Overexpression Lysate (Adult Normal) [NBL1-11812] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ICT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6691_ICT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11812-img0002.jpg)