Gene Symbol | ICT1 |
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Entrez Gene | 3396 |
Alt Symbol | DS-1, DS1, MRP-L58 |
Species | Human |
Gene Type | protein-coding |
Description | immature colon carcinoma transcript 1 |
Other Description | 39S ribosomal protein L58, mitochondrial|digestion substraction 1|immature colon carcinoma transcript 1 protein|peptidyl-tRNA hydrolase ICT1, mitochondrial |
Swissprots | Q53HM7 Q53Y11 B2RAD1 Q14197 |
Accessions | EAW89227 Q14197 AK222553 BAD96273 AK314138 BAG36828 BC015335 AAH15335 BI870683 BT007111 AAP35775 DB456649 DQ890655 ABM81581 DQ893834 ABM84760 X81788 CAA57387 NM_001303265 NP_001290194 NM_001545 NP_001536 |
Function | Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. {ECO:0000269|PubMed:20186120}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:23908630}. |
Tissue Specificity | Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells. {ECO:0000269|PubMed:8575443}. |
ICT1 CRISPR/Cas9 KO Plasmid (h) - sc-408653 from Santa Cruz Biotechnology
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ICT1 HDR Plasmid (h) - sc-408653-HDR from Santa Cruz Biotechnology
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ICT1 Double Nickase Plasmid (h) - sc-408653-NIC from Santa Cruz Biotechnology
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ICT1 Double Nickase Plasmid (h2) - sc-408653-NIC-2 from Santa Cruz Biotechnology
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ICT1 CRISPR Activation Plasmid (h) - sc-408653-ACT from Santa Cruz Biotechnology
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ICT1 CRISPR Activation Plasmid (h2) - sc-408653-ACT-2 from Santa Cruz Biotechnology
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ICT1 Lentiviral Activation Particles (h) - sc-408653-LAC from Santa Cruz Biotechnology
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ICT1 Lentiviral Activation Particles (h2) - sc-408653-LAC-2 from Santa Cruz Biotechnology
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ICT1 siRNA (h) - sc-94120 from Santa Cruz Biotechnology
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ICT1 shRNA Plasmid (h) - sc-94120-SH from Santa Cruz Biotechnology
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ICT1 shRNA (h) Lentiviral Particles - sc-94120-V from Santa Cruz Biotechnology
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ICT RNAi - H00003396-R01 from Novus Biologicals
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MISSION® esiRNA - EHU021891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10435 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10435 from Sigma-Aldrich
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ICT1 siRNA (Human) - CRH2306 from Cohesion Biosciences
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ICT1 - MBS8218128 from MyBioSource
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shRNA set against Human ICT1(NM_001545.1) - SHL164370 from Creative biogene
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Human ICT1 siRNA - orb262808 from Biorbyt
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ICT1 shRNA Plasmid (Human) - CHH2306 from Cohesion Biosciences
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ICT1 miRNA 3'UTR clone - MiUTR1H-04785 from Creative biogene
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