Gene Symbol | CCNT2 |
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Entrez Gene | 905 |
Alt Symbol | CYCT2 |
Species | Human |
Gene Type | protein-coding |
Description | cyclin T2 |
Other Description | SDS-stable vimentin-bound DNA fragment HEF42VIM22|cyclin T2a|cyclin T2b|cyclin-T2|subunit of positive elongation transcription factor b |
Swissprots | O60582 Q5I1Y0 D3DP74 O60583 Q53SR4 Q29R66 D3DP73 A8KA48 |
Accessions | AAW56073 AAY14998 EAX11644 EAX11645 EAX11646 EAX11647 O60583 AF048731 AAC39665 AF048732 AAC39666 AK023645 AK075041 AK292913 BAF85602 AK294889 BAG57982 AU157699 BC114366 AAI14367 BX648174 XM_006712827 XP_006712890 XM_011512132 XP_011510434 XM_011512133 XP_011510435 XM_011512134 XP_011510436 NM_001241 NP_001232 NM_058241 NP_490595 NR_037649 |
Function | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). {ECO:0000269|PubMed:10364329}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Ubiquitously expressed. |
Top Pathways | Transcriptional misregulation in cancer |
cyclin T2a/b CRISPR/Cas9 KO Plasmid (h) - sc-404586 from Santa Cruz Biotechnology
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cyclin T2a/b HDR Plasmid (h) - sc-404586-HDR from Santa Cruz Biotechnology
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cyclin T2a/b Double Nickase Plasmid (h) - sc-404586-NIC from Santa Cruz Biotechnology
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cyclin T2a/b Double Nickase Plasmid (h2) - sc-404586-NIC-2 from Santa Cruz Biotechnology
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cyclin T2a/b CRISPR Activation Plasmid (h) - sc-404586-ACT from Santa Cruz Biotechnology
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cyclin T2a/b CRISPR Activation Plasmid (h2) - sc-404586-ACT-2 from Santa Cruz Biotechnology
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cyclin T2a/b Lentiviral Activation Particles (h) - sc-404586-LAC from Santa Cruz Biotechnology
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cyclin T2a/b Lentiviral Activation Particles (h2) - sc-404586-LAC-2 from Santa Cruz Biotechnology
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cyclin T2a/b siRNA (h) - sc-37601 from Santa Cruz Biotechnology
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cyclin T2a shRNA Plasmid (h)-SH - sc-37601-SH from Santa Cruz Biotechnology
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cyclin T2a shRNA (h) Lentiviral Particles - sc-37601-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU080391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5650 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5650 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11402 from Sigma-Aldrich
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CCNT2 siRNA (Human) - CRH0636 from Cohesion Biosciences
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CCNT2 - MBS8219972 from MyBioSource
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shRNA set against Human CCNT2 (NM_001241.3) - SHH258053 from Creative biogene
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Human CCNT2 siRNA - orb261138 from Biorbyt
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CCNT2 shRNA Plasmid (Human) - CHH0636 from Cohesion Biosciences
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CCNT2 miRNA 3'UTR clone - MiUTR4H-TG10826 from Creative biogene
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