PCSK1N

Gene Symbol	PCSK1N
Entrez Gene	27344
Alt Symbol	PROSAAS, SAAS, SCG8, SgVIII
Species	Human
Gene Type	protein-coding
Description	proprotein convertase subtilisin/kexin type 1 inhibitor
Other Description	granin-like neuroendocrine peptide|pro-SAAS|proSAAS|proprotein convertase 1 inhibitor
Swissprots	Q9UHG2 Q4VC04
Accessions	EAW50742 Q9UHG2 AA706516 AF181562 AAF22643 BC002851 AAH02851 BC094731 BX459856 DQ893525 ABM84451 HY114016 HY348068 NM_013271 NP_037403
Function	May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease). {ECO:0000269|PubMed:12914799, ECO:0000269|PubMed:14746899}.
Tissue Specificity	Expressed in brain and pancreas. {ECO:0000269|PubMed:10632593}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PCSK1N (V-14) - sc-241600 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ProSAAS antibody - ab118352 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ProSAAS antibody - ab72649 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PCSK1N / PROSAAS Antibody (aa221-242) - LS-C144116 from LifeSpan Bioscience Prices $740.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

Anti-PCSK1N / PROSAAS Antibody (aa54-103) - LS-C170303 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PCSK1N / PROSAAS Antibody (clone 1E9) - LS-C134062 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E9

Anti-PCSK1N / PROSAAS Antibody (aa182-193) IHC-plus™ - LS-B10595 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

PCSK1N Antibody - NBP1-80797 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PCSK1N Antibody - H00027344-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

PCSK1N Antibody - H00027344-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

PCSK1N Antibody (1E9) - H00027344-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E9

PROSAAS Polyclonal Antibody - bs-11686R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11686R-A350 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11686R-A488 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11686R-A555 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11686R-A647 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, Cy3 Conjugated - bs-11686R-Cy3 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, Cy5 Conjugated - bs-11686R-Cy5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, Cy5.5 Conjugated - bs-11686R-Cy5.5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, Cy7 Conjugated - bs-11686R-Cy7 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, FITC Conjugated - bs-11686R-FITC from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, Biotin Conjugated - bs-11686R-Biotin from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-PROSAAS Polyclonal Antibody, HRP Conjugated - bs-11686R-HRP from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PCSK1N antibody produced in mouse - SAB1401647 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Monoclonal Anti-PCSK1N, (C-terminal) antibody produced in mouse - SAB1402570 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E9

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