PCSK1N

Gene Symbol	PCSK1N
Entrez Gene	27344
Alt Symbol	PROSAAS, SAAS, SCG8, SgVIII
Species	Human
Gene Type	protein-coding
Description	proprotein convertase subtilisin/kexin type 1 inhibitor
Other Description	granin-like neuroendocrine peptide|pro-SAAS|proSAAS|proprotein convertase 1 inhibitor
Swissprots	Q9UHG2 Q4VC04
Accessions	EAW50742 Q9UHG2 AA706516 AF181562 AAF22643 BC002851 AAH02851 BC094731 BX459856 DQ893525 ABM84451 HY114016 HY348068 NM_013271 NP_037403
Function	May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease). {ECO:0000269|PubMed:12914799, ECO:0000269|PubMed:14746899}.
Tissue Specificity	Expressed in brain and pancreas. {ECO:0000269|PubMed:10632593}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ProSAAS (PCSK1N), Human, ELISA Kit - CSB-EL017641HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

proprotein convertase subtilisin/kexin type 1 inhibitor, ELISA Kit - MBS946045 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PCSK1N is typically less than 0.078 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.312 ng/ml -20 ng/ml.

Human ProSAAS(PCSK1N) ELISA kit - CSB-EL017641HU from Cusabio Category ELISA Kit Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Human ProSAAS (PCSK1N) ELISA Kit - EKC35150 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

ProSAAS/PCSK1N - EKH8414 from Nordic BioSite Sensitivity 0.078 ng/ml Range 0.312-20ng/ml

Human PCSK1N ELISA Kit - E031198 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PCSK1N is typically less than 0.078 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

Human ProSAAS/PCSK1N ELISA Kit - E031214 from Biobool Category ELISA Kit Sensitivity < 0.078 ng/ml

PCSK1N ELISA Kit (Human) (OKCA00766) - OKCA00766 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 0.078 ng/mL Range 0.312 ng/mL-20 ng/mL

Human ProSAAS ELISA Kit - EK4640 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 29pg/mL Range 78-5000 pg/mL

ProSAAS, ELISA Kit - MBS9428466 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.312-20 ng/mL

ProSAAS/PCSK1N (granin-like neuroendocrine peptide), ELISA Kit - MBS766146 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.078 ng/ml Range 0.312-20ng/ml

Human PCSK1N / PROSAAS ELISA Kit (Sandwich ELISA) - LS-F32545 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.078 Range 0.312-20 ng/ml

Human PCSK1N ELISA Kit - orb405079 from Biorbyt Category ELISA Kit Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Search more