| Gene Symbol | PCSK1N |
|---|---|
| Entrez Gene | 27344 |
| Alt Symbol | PROSAAS, SAAS, SCG8, SgVIII |
| Species | Human |
| Gene Type | protein-coding |
| Description | proprotein convertase subtilisin/kexin type 1 inhibitor |
| Other Description | granin-like neuroendocrine peptide|pro-SAAS|proSAAS|proprotein convertase 1 inhibitor |
| Swissprots | Q9UHG2 Q4VC04 |
| Accessions | EAW50742 Q9UHG2 AA706516 AF181562 AAF22643 BC002851 AAH02851 BC094731 BX459856 DQ893525 ABM84451 HY114016 HY348068 NM_013271 NP_037403 |
| Function | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease). {ECO:0000269|PubMed:12914799, ECO:0000269|PubMed:14746899}. |
| Tissue Specificity | Expressed in brain and pancreas. {ECO:0000269|PubMed:10632593}. |
PCSK1N CRISPR/Cas9 KO Plasmid (h) - sc-411996 from Santa Cruz Biotechnology
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PCSK1N HDR Plasmid (h) - sc-411996-HDR from Santa Cruz Biotechnology
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PCSK1N Double Nickase Plasmid (h) - sc-411996-NIC from Santa Cruz Biotechnology
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PCSK1N Double Nickase Plasmid (h2) - sc-411996-NIC-2 from Santa Cruz Biotechnology
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PCSK1N CRISPR Activation Plasmid (h) - sc-411996-ACT from Santa Cruz Biotechnology
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PCSK1N CRISPR Activation Plasmid (h2) - sc-411996-ACT-2 from Santa Cruz Biotechnology
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PCSK1N Lentiviral Activation Particles (h) - sc-411996-LAC from Santa Cruz Biotechnology
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PCSK1N Lentiviral Activation Particles (h2) - sc-411996-LAC-2 from Santa Cruz Biotechnology
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PCSK1N siRNA (h) - sc-91290 from Santa Cruz Biotechnology
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PCSK1N shRNA Plasmid (h) - sc-91290-SH from Santa Cruz Biotechnology
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PCSK1N shRNA (h) Lentiviral Particles - sc-91290-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU058461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16499 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16499 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00290 from Sigma-Aldrich
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PCSK1N siRNA (Human) - CRH9093 from Cohesion Biosciences
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shRNA set against Human PCSK1N (NM_013271.2) - SHH372004 from Creative biogene
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shRNA set against Human PCSK1N(NM_013271.2) - SHR097708 from Creative biogene
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Human PCSK1N siRNA - orb269595 from Biorbyt
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PCSK1N shRNA Plasmid (Human) - CHH9093 from Cohesion Biosciences
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PCSK1N miRNA 3'UTR clone - MiUTR1H-07681 from Creative biogene
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