RAPGEF4

Gene Symbol	RAPGEF4
Entrez Gene	11069
Alt Symbol	2, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496
Species	Human
Gene Type	protein-coding
Description	Rap guanine nucleotide exchange factor (GEF) 4
Other Description	RAP guanine-nucleotide-exchange factor (GEF) 4|cAMP-regulated guanine nucleotide exchange factor II|exchange factor directly activated by cAMP 2|exchange protein directly activated by cAMP 2|putative protein product of Nbla00496|rap guanine nucleotide exchange factor 4
Swissprots	Q8WZA2 B7Z912 Q8IXK6 B7Z3T6 O95636 B7Z283 B2R7R3 Q8TAA4
Accessions	AAY15071 AAY24186 CDM22142 EAX11167 EAX11168 EAX11169 Q8WZA2 AB027471 BAB72179 AB075513 BAE45759 AB209681 BAD92918 AK294433 BAH11764 AK294445 BAH11769 AK294914 BAH11923 AK294997 BAH11944 AK295002 BAH11946 AK296340 BAH12322 AK302732 BAH13791 AK304278 BAH14148 AK310373 AK311165 AK311500 AK311575 AK311697 AK313084 BAG35910 AK316014 BAH14385 AK316072 BAH14443 BC024004 AAH24004 BC040183 AAH40183 BI546558 BQ184791 DB471672 DC335305 DQ890549 ABM92166 DQ894011 ABM84937 KJ534924 AHW56564 KJ534925 AHW56565 KJ534978 AHW56618 U78516 AAD03422 XM_005246246 XP_005246303 XM_006712205 XP_006712268 XM_011510505 XP_011508807 NM_001100397 NP_001093867 NM_001282899 NP_001269828 NM_001282900 NP_001269829 NM_001282901 NP_001269830 NM_007023 NP_008954
Function	Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
Top Pathways	Leukocyte transendothelial migration, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Epac2 full length protein - ab153155 from Abcam Category Protein Source Wheat germ Species Human

Human Epac2 protein fragment - ab153156 from Abcam Category Protein Source Wheat germ Species Human

RAPGEF4 / EPAC2 Antibody Blocking Peptide - LS-E31212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Epac2 Protein - H00011069-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Epac2 Protein - H00011069-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAPGEF4-Antibody-N-term-Blocking-Peptide - BP6998a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Apolipoprotein L2 blocking peptide - GTX88507-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

CITED2 (C Terminus) blocking peptide - GTX89845-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

CITED2 (Internal) blocking peptide - GTX89415-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

PSMD2 blocking peptide - GTX89633-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

XAGE1 (Isoform 1d)/GAGED2 blocking peptide - GTX89612-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

XAGE1 (Isoforms 1a, 1b and 1c) blocking peptide - GTX89688-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

SARS-ACN/2 protein - orb97845 from Biorbyt Category Protein Prices $383.00 Sizes 100 μg

Bacterial ERK1/2 protein - orb81538 from Biorbyt Category Protein Prices $323.00, $595.00, $1,139.00 Sizes 100 μg, 500 μg, 1000 μg Species Bacteria

HIV-1, 2 protein - orb81728 from Biorbyt Category Protein Prices $323.00, $595.00, $961.00 Sizes 100 μg, 500 μg, 1000 μg

Bcl2 protein (His tag) - 80R-1136 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

BPGM protein (His tag) - 80R-1292 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

Catenin alpha 1/2 Blocking Peptide - abx062486 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Pig

RAPGEF4 - H00011069-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAPGEF4 - H00011069-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAPGEF4 - H00011069-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAPGEF4 - H00011069-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAPGEF4 control peptide - AP09997CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

RAPGEF4 (N-term) Control Peptide - AP55604CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

EPAC2 Peptide - 6633P from ProSci Category Peptide Species Human

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