RAPGEF4
| Gene Symbol | RAPGEF4 |
|---|---|
| Entrez Gene | 11069 |
| Alt Symbol | 2, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rap guanine nucleotide exchange factor (GEF) 4 |
| Other Description | RAP guanine-nucleotide-exchange factor (GEF) 4|cAMP-regulated guanine nucleotide exchange factor II|exchange factor directly activated by cAMP 2|exchange protein directly activated by cAMP 2|putative protein product of Nbla00496|rap guanine nucleotide exchange factor 4 |
| Swissprots | Q8WZA2 B7Z912 Q8IXK6 B7Z3T6 O95636 B7Z283 B2R7R3 Q8TAA4 |
| Accessions | AAY15071 AAY24186 CDM22142 EAX11167 EAX11168 EAX11169 Q8WZA2 AB027471 BAB72179 AB075513 BAE45759 AB209681 BAD92918 AK294433 BAH11764 AK294445 BAH11769 AK294914 BAH11923 AK294997 BAH11944 AK295002 BAH11946 AK296340 BAH12322 AK302732 BAH13791 AK304278 BAH14148 AK310373 AK311165 AK311500 AK311575 AK311697 AK313084 BAG35910 AK316014 BAH14385 AK316072 BAH14443 BC024004 AAH24004 BC040183 AAH40183 BI546558 BQ184791 DB471672 DC335305 DQ890549 ABM92166 DQ894011 ABM84937 KJ534924 AHW56564 KJ534925 AHW56565 KJ534978 AHW56618 U78516 AAD03422 XM_005246246 XP_005246303 XM_006712205 XP_006712268 XM_011510505 XP_011508807 NM_001100397 NP_001093867 NM_001282899 NP_001269828 NM_001282900 NP_001269829 NM_001282901 NP_001269830 NM_007023 NP_008954 |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. |
| Top Pathways | Leukocyte transendothelial migration, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Rap1 signaling pathway |
Epac2 CRISPR/Cas9 KO Plasmid (h) - sc-402096 from Santa Cruz Biotechnology
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Epac2 HDR Plasmid (h) - sc-402096-HDR from Santa Cruz Biotechnology
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Epac2 Double Nickase Plasmid (h) - sc-402096-NIC from Santa Cruz Biotechnology
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Epac2 Double Nickase Plasmid (h2) - sc-402096-NIC-2 from Santa Cruz Biotechnology
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Epac2 CRISPR Activation Plasmid (h) - sc-402096-ACT from Santa Cruz Biotechnology
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Epac2 CRISPR Activation Plasmid (h2) - sc-402096-ACT-2 from Santa Cruz Biotechnology
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Epac2 Lentiviral Activation Particles (h) - sc-402096-LAC from Santa Cruz Biotechnology
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Epac2 Lentiviral Activation Particles (h2) - sc-402096-LAC-2 from Santa Cruz Biotechnology
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Epac2 siRNA (h) - sc-41702 from Santa Cruz Biotechnology
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Epac2 shRNA Plasmid (h) - sc-41702-SH from Santa Cruz Biotechnology
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Epac2 shRNA (h) Lentiviral Particles - sc-41702-V from Santa Cruz Biotechnology
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Epac2 RNAi - H00011069-R02 from Novus Biologicals
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MISSION® esiRNA - EHU080731 from Sigma-Aldrich
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MISSION® siRNA - SIHK1936 from Sigma-Aldrich
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MISSION® siRNA - SIHK1938 from Sigma-Aldrich
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MISSION® siRNA - SIHK1939 from Sigma-Aldrich
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MISSION® siRNA - SIHK1937 from Sigma-Aldrich
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MISSION® siRNA - SIHK1940 from Sigma-Aldrich
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MISSION® siRNA - SIHK1935 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17956 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17956 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07891 from Sigma-Aldrich
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RAPGEF4 siRNA (Human) - CRH7567 from Cohesion Biosciences
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Epac2 RNAi - H00011069-R01 from Novus Biologicals
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RAPGEF4 - MBS8215624 from MyBioSource
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