| Gene Symbol |
IRX5
|
| Entrez Gene |
10265
|
| Alt Symbol |
HMMS, IRX-2a, IRXB2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
iroquois homeobox 5
|
| Other Description |
homeodomain protein IRX-2A|homeodomain protein IRXB2|iroquois-class homeodomain protein IRX-5
|
| Swissprots |
Q7Z2E1 P78411 P78416 H0YMS7
|
| Accessions |
AAQ16550 CBX47594 P78411 AY335945 AAQ16551 BC074850 BC131510 AAI31511 U90304 AAB50002 U90309 AAB50007 XM_011522809 XP_011521111 NM_001252197 NP_001239126 NM_005853 NP_005844
|
| Function |
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|