| Gene Symbol | ITSN2 |
|---|---|
| Entrez Gene | 50618 |
| Alt Symbol | PRO2015, SH3D1B, SH3P18, SWA, SWAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | intersectin 2 |
| Other Description | SH3 domain-containing protein 1B|SH3P18-like WASP-associated protein|intersectin-2 |
| Swissprots | Q9HAK4 O95062 Q9NZM3 Q9NYG0 Q9NXE6 Q9NZM2 Q15812 Q9ULG4 |
| Accessions | AAX93122 AAX93123 AAY14668 EAX00750 EAX00751 EAX00752 EAX00753 Q9NZM3 AB033082 BAA86570 AF001630 AAD00899 AF038189 AF182198 AAF59903 AF182199 AAF59904 AF248540 AAF63600 AK000302 BAA91068 AK021545 BAB13841 AK025400 AK091859 BC020921 AAH20921 BC038963 AAH38963 BC146779 AAI46780 DA382952 U61167 AAC50593 NM_006277 NP_006268 NM_019595 NP_062541 NM_147152 NP_671494 |
| Function | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver. |
Human ITSN2 cDNA clone(NM_019595.3) - CDFG002322 from Creative Biomart
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Human ITSN2 cDNA clone(NM_147152.2) - CDFG009165 from Creative Biomart
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Human ITSN2 cDNA clone(NM_006277.2) - CDFH009499 from Creative Biomart
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Human ITSN2 ORF Clone(NM_006277.2) - CDCL167530 from Creative Biomart
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Human ITSN2 ORF Clone(NM_006277.2) - CDCR292497 from Creative Biomart
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Human ITSN2 ORF Clone(NM_006277.2) - CDCR292498 from Creative Biomart
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Human ITSN2 ORF Clone(NM_006277.2) - CDCR292499 from Creative Biomart
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Human ITSN2 ORF Clone(NM_006277.2) - CDCR292500 from Creative Biomart
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Human ITSN2 ORF Clone(NM_019595.3) - CDCR304722 from Creative Biomart
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Human ITSN2 ORF Clone(NM_019595.3) - CDCR304723 from Creative Biomart
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Human ITSN2 ORF Clone(NM_019595.3) - CDCR304724 from Creative Biomart
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Human ITSN2 ORF Clone(NM_019595.3) - CDCR304725 from Creative Biomart
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Human ITSN2 ORF Clone(NM_147152.2) - CDCR318791 from Creative Biomart
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Human ITSN2 ORF Clone(NM_147152.2) - CDCR318792 from Creative Biomart
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Human ITSN2 ORF Clone(NM_147152.2) - CDCR318793 from Creative Biomart
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Human ITSN2 ORF Clone(NM_147152.2) - CDCR318794 from Creative Biomart
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Human ITSN2 ORF clone (NM_006277.2) - CDCL122215 from Creative biogene
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Mouse ITSN2 ORF clone (NM_019595.3) - CDCL122217 from Creative biogene
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Mouse ITSN2 ORF clone (NM_147152.2) - CDCL122219 from Creative biogene
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Human ITSN2 cDNA Clone(NM_019595.3) - CDFG002322 from Creative biogene
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Human ITSN2 cDNA Clone(NM_147152.2) - CDFG009165 from Creative biogene
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Human ITSN2 cDNA Clone(NM_006277.2) - CDFH009499 from Creative biogene
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