Gene Symbol | HSD17B14 |
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Entrez Gene | 51171 |
Alt Symbol | DHRS10, SDR47C1, retSDR3 |
Species | Human |
Gene Type | protein-coding |
Description | hydroxysteroid (17-beta) dehydrogenase 14 |
Other Description | 17-beta-HSD 14|17-beta-hydroxysteroid dehydrogenase 14|17-beta-hydroxysteroid dehydrogenase DHRS10|dehydrogenase/reductase (SDR family) member 10|dehydrogenase/reductase SDR family member 10|retinal short-chain dehydrogenase/reductase 3|retinal short-chain dehydrogenase/reductase retSDR3|short chain dehydrogenase/reductase family 47C member 1|short chain dehydrogenase/reductase family 47C, member 1 |
Swissprots | Q9UKU3 Q9BPX1 |
Accessions | EAW52404 Q9BPX1 AF126781 AAF06940 AK307437 AY358430 AAQ88796 BC006283 AAH06283 BC006294 AAH06294 BI602824 HQ448038 ADQ32519 XM_005258969 XP_005259026 XM_005258970 XP_005259027 XR_243938 NM_016246 NP_057330 |
Function | Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). {ECO:0000269|PubMed:17067289}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17067289}. |
Tissue Specificity | Highly expressed in brain, placenta, liver and kidney. {ECO:0000269|PubMed:10800688, ECO:0000269|PubMed:17067289}. |
17β-HSD14 siRNA (h) - sc-97848 from Santa Cruz Biotechnology
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17β-HSD14 shRNA Plasmid (h) - sc-97848-SH from Santa Cruz Biotechnology
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17β-HSD14 shRNA (h) Lentiviral Particles - sc-97848-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU160231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10326 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10326 from Sigma-Aldrich
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HSD17B14 siRNA (Human) - CRH9580 from Cohesion Biosciences
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HSD17B14 - MBS8232678 from MyBioSource
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shRNA set against Human HSD17B14 (NM_016246.2) - SHH315193 from Creative biogene
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HSD17B14 shRNA Plasmid (Human) - CHH9580 from Cohesion Biosciences
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HSD17B14 miRNA 3'UTR clone - MiUTR1H-04716 from Creative biogene
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