MAPK3

Gene Symbol	MAPK3
Entrez Gene	5595
Alt Symbol	ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 3
Other Description	MAP kinase isoform p44|MAPK 1|extracellular signal-regulated kinase 1|extracellular signal-related kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase
Swissprots	Q8NHX1 P27361 A8CZ58 B0LPG3
Accessions	ABY87542 AGC09597 CBK51145 EAW79912 EAW79913 EAW79914 EAW79915 EAW79916 EAW79917 P27361 AK091009 BAG52261 AK307995 AY033607 AAK52329 AY033608 AAK52330 BC000205 AAH00205 BC013992 AAH13992 BX537897 CAD97888 DA351318 DQ399291 ABD60302 DQ893440 ABM84366 DQ896778 ABM87777 KJ534878 AHW56518 M84490 AAA36142 X60188 CAA42744 Z11696 CAA77754 XR_243293 NM_001040056 NP_001035145 NM_001109891 NP_001103361 NM_002746 NP_002737
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
Subcellular Location	Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.
Top Pathways	TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ERK1 full length protein - ab105904 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source E. coli Species Human

Active human ERK1 full length protein - ab116536 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Active human ERK1 full length protein - ab90409 from Abcam Category Protein Prices $317.00 Sizes 20 µg Source E. coli Species Human

ERK1 peptide - ab7991 from Abcam Category Peptide

ERK1 peptide (10-21) - ab45733 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human ERK1 (mutated K71 A) full length protein - ab125557 from Abcam Category Protein Source E. coli Species Human

Human ERK1 full length protein - ab126906 from Abcam Category Protein Source E. coli Species Human

Human ERK1 full length protein - ab43623 from Abcam Category Protein Source E. coli Species Human

ERK1/2-T202/Y204 Antibody Blocking Peptide - LS-E7436 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E3126 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E20484 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E20485 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E28769 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E28653 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E28654 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAPK3 / ERK1 Antibody Blocking Peptide - LS-E25875 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERK1/2-T202/Y204 Antibody Blocking Peptide - LS-E9008 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERK1/2 Peptide - NBP1-97853PEP from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg Species Human, Mouse, Rat, Chicken, Sheep

ERK1 Recombinant Protein - H00005595-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERK1 Partial Recombinant Protein - H00005595-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERK1 Recombinant Protein - P4224 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human ERK1/2 Protein - P4688 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant ERK1 Protein - NBP1-99512 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Recombinant Human ERK1 Protein - NBP1-48333 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

ERK1 Peptide - P2500 from Novus Biologicals Category Peptide Species Human

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