MAPK3

Gene Symbol	MAPK3
Entrez Gene	5595
Alt Symbol	ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 3
Other Description	MAP kinase isoform p44|MAPK 1|extracellular signal-regulated kinase 1|extracellular signal-related kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase
Swissprots	Q8NHX1 P27361 A8CZ58 B0LPG3
Accessions	ABY87542 AGC09597 CBK51145 EAW79912 EAW79913 EAW79914 EAW79915 EAW79916 EAW79917 P27361 AK091009 BAG52261 AK307995 AY033607 AAK52329 AY033608 AAK52330 BC000205 AAH00205 BC013992 AAH13992 BX537897 CAD97888 DA351318 DQ399291 ABD60302 DQ893440 ABM84366 DQ896778 ABM87777 KJ534878 AHW56518 M84490 AAA36142 X60188 CAA42744 Z11696 CAA77754 XR_243293 NM_001040056 NP_001035145 NM_001109891 NP_001103361 NM_002746 NP_002737
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
Subcellular Location	Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.
Top Pathways	TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p44/42 MAPK (Erk1/2) siRNA - 6560 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® p44 MAPK (Erk1) siRNA I - 6436 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

ERK 1 CRISPR/Cas9 KO Plasmid (h) - sc-400010 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 HDR Plasmid (h) - sc-400010-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 Double Nickase Plasmid (h) - sc-400010-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 Double Nickase Plasmid (h2) - sc-400010-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 CRISPR Activation Plasmid (h) - sc-400010-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 CRISPR Activation Plasmid (h2) - sc-400010-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 Lentiviral Activation Particles (h) - sc-400010-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 Lentiviral Activation Particles (h2) - sc-400010-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 1 siRNA (h) - sc-29307 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 1 shRNA Plasmid (h) - sc-29307-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 1 shRNA (h) Lentiviral Particles - sc-29307-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 1 siRNA (h2) - sc-44205 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 1 shRNA Plasmid (h2) - sc-44205-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 1 shRNA (h2) Lentiviral Particles - sc-44205-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK1 RNAi - H00005595-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU062481 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1209 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1207 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1208 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1351 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1351 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MAPK3 siRNA (Human) - CRH3765 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ERK 1 CRISPR/Cas9 KO Plasmid (h2) - sc-400010-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

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