HNRNPC
| Gene Symbol | HNRNPC |
|---|---|
| Entrez Gene | 3183 |
| Alt Symbol | C1, C2, HNRNP, HNRPC, SNRPC |
| Species | Human |
| Gene Type | protein-coding |
| Description | heterogeneous nuclear ribonucleoprotein C (C1/C2) |
| Other Description | heterogeneous nuclear ribonucleoproteins C1/C2|hnRNP C1/C2|nuclear ribonucleoprotein particle C1 protein|nuclear ribonucleoprotein particle C2 protein |
| Swissprots | P07910 Q86U45 Q86SF8 Q59FD3 Q53EX2 D3DS19 Q96IY5 D3DS22 Q9BTS3 Q96HK7 P22628 Q5FWE8 Q96HM4 |
| Accessions | CAH05635 EAW66392 EAW66393 EAW66394 EAW66395 EAW66396 EAW66397 EAW66398 EAW66399 EAW66400 P07910 AB209527 BAD92764 AK126950 BAG54408 AK223517 BAD97237 AK225032 AK292619 BAF85308 AK297482 BAG59903 AK298906 BAG61014 AK299923 BAG61758 AK302213 BAG63570 AK312338 BAG35259 AK312382 BAG35300 AL833432 BC003394 AAH03394 BC007052 AAH07052 BC008364 AAH08364 BC008423 AAH08423 BC066932 AAH66932 BC071943 BC089438 AAH89438 BC092433 AAH92433 BC103758 AAI03759 BC108658 AAI08659 BX161480 CAD61934 BX247961 CAD62300 BX247992 CAD62326 D28382 BAA05748 DB449514 HQ258021 ADR82775 M16342 AAA52680 M29063 AAA36576 Z70766 XM_006720125 XP_006720188 XM_011536708 XP_011535010 XM_011536709 XP_011535011 XM_011536710 XP_011535012 XM_011536711 XP_011535013 XM_011536712 XP_011535014 NM_001077442 NP_001070910 NM_001077443 NP_001070911 NM_004500 NP_004491 NM_031314 NP_112604 |
| Function | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| Subcellular Location | Nucleus. Note=Component of ribonucleosomes. |
| Top Pathways | Spliceosome |
hnRNP C1/C2 CRISPR/Cas9 KO Plasmid (h) - sc-400993 from Santa Cruz Biotechnology
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hnRNP C1/C2 HDR Plasmid (h) - sc-400993-HDR from Santa Cruz Biotechnology
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hnRNP C1/C2 Double Nickase Plasmid (h) - sc-400993-NIC from Santa Cruz Biotechnology
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hnRNP C1/C2 Double Nickase Plasmid (h2) - sc-400993-NIC-2 from Santa Cruz Biotechnology
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hnRNP C1/C2 CRISPR Activation Plasmid (h) - sc-400993-ACT from Santa Cruz Biotechnology
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hnRNP C1/C2 CRISPR Activation Plasmid (h2) - sc-400993-ACT-2 from Santa Cruz Biotechnology
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hnRNP C1/C2 Lentiviral Activation Particles (h) - sc-400993-LAC from Santa Cruz Biotechnology
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hnRNP C1/C2 Lentiviral Activation Particles (h2) - sc-400993-LAC-2 from Santa Cruz Biotechnology
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hnRNP C1/C2 siRNA (h) - sc-35577 from Santa Cruz Biotechnology
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hnRNP C1/C2 shRNA Plasmid (h) - sc-35577-SH from Santa Cruz Biotechnology
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hnRNP C1/C2 shRNA (h) Lentiviral Particles - sc-35577-V from Santa Cruz Biotechnology
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SNRPC RNAi - H00006631-R01 from Novus Biologicals
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hnRNP C1 + C2 RNAi - H00003183-R01 from Novus Biologicals
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hnRNP C1 + C2 RNAi - H00003183-R02 from Novus Biologicals
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MISSION® esiRNA - EHU133931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10200 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10200 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11046 from Sigma-Aldrich
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HNRNPC siRNA (Human) - CRH2174 from Cohesion Biosciences
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HNRNPC - MBS8224951 from MyBioSource
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shRNA set against Human HNRPC(NM_001077443.1) - SHH126767 from Creative biogene
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shRNA set against Human HNRPC(NM_001077442.1) - SHH126803 from Creative biogene
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Human HNRNPC siRNA - orb262676 from Biorbyt
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HNRNPC shRNA Plasmid (Human) - CHH2174 from Cohesion Biosciences
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HNRNPC miRNA 3'UTR clone - MiUTR1H-04629 from Creative biogene
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