Gene Symbol | EOGT |
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Entrez Gene | 285203 |
Alt Symbol | AER61, AOS4, C3orf64, EOGT1 |
Species | Human |
Gene Type | protein-coding |
Description | EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase |
Other Description | AER61 glycosyltransferase|EGF domain-specific O-linked N-acetylglucosamine transferase|EGF-O-GlcNAc transferase|extracellular O-linked N-acetylglucosamine transferase |
Swissprots | Q6ZTV0 Q6P985 L7X1M5 B4DFH5 A8K2U1 Q5NDL2 Q6MZY0 |
Accessions | Q5NDL2 AA709285 AJ868234 CAI30569 AK023140 AK091089 BAG52283 AK123213 AK126187 BAC86479 AK290356 BAF83045 AK294101 BAG57436 AK304102 BAG65005 AL833467 BC028935 AAH28935 BC060887 AAH60887 BX640821 CAE45897 BX648818 DA856791 HQ448550 ADQ33029 KC347596 AGC92970 XM_005264743 XP_005264800 XM_011533599 XP_011531901 XM_011533600 XP_011531902 XM_011533601 XP_011531903 XM_011533602 XP_011531904 XM_011533603 XP_011531905 XM_011533604 XP_011531906 XM_011533605 XP_011531907 NM_001278689 NP_001265618 NM_173654 NP_775925 NR_103826 |
Function | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. {ECO:0000269|PubMed:23671640}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. |
Top Pathways | Other types of O-glycan biosynthesis |
EOGT CRISPR/Cas9 KO Plasmid (h) - sc-418490 from Santa Cruz Biotechnology
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EOGT HDR Plasmid (h) - sc-418490-HDR from Santa Cruz Biotechnology
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EOGT Double Nickase Plasmid (h) - sc-418490-NIC from Santa Cruz Biotechnology
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EOGT Double Nickase Plasmid (h2) - sc-418490-NIC-2 from Santa Cruz Biotechnology
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EOGT CRISPR Activation Plasmid (h) - sc-418490-ACT from Santa Cruz Biotechnology
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EOGT CRISPR Activation Plasmid (h2) - sc-418490-ACT-2 from Santa Cruz Biotechnology
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EOGT Lentiviral Activation Particles (h) - sc-418490-LAC from Santa Cruz Biotechnology
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EOGT Lentiviral Activation Particles (h2) - sc-418490-LAC-2 from Santa Cruz Biotechnology
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EOGT siRNA (h) - sc-78525 from Santa Cruz Biotechnology
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EOGT shRNA Plasmid (h) - sc-78525-SH from Santa Cruz Biotechnology
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EOGT shRNA (h) Lentiviral Particles - sc-78525-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4915 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4915 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11449 from Sigma-Aldrich
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EOGT siRNA (Human) - CRJ7076 from Cohesion Biosciences
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EOGT - MBS8235668 from MyBioSource
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shRNA set against Human C3orf64 (NM_173654.1) - SHH251733 from Creative biogene
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EOGT shRNA Plasmid (Human) - CHJ7076 from Cohesion Biosciences
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EOGT miRNA 3'UTR clone - MiUTR1H-01400 from Creative biogene
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