Gene Symbol | SF1 |
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Entrez Gene | 7536 |
Alt Symbol | BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 |
Species | Human |
Gene Type | protein-coding |
Description | splicing factor 1 |
Other Description | mammalian branch point-binding protein|transcription factor ZFM1|zinc finger gene in MEN1 locus|zinc finger protein 162 |
Swissprots | Q969H7 B7Z1Q1 C9JJE2 Q9BW01 Q14819 Q15913 Q92744 Q14818 Q15637 Q8IY00 Q92745 Q9UEI0 |
Accessions | CAA03883 CCO13811 EAW74286 EAW74287 EAW74288 EAW74289 EAW74290 EAW74291 EAW74292 EAW74293 EAW74294 EAW74295 EAW74296 EAW74297 Q15637 AI492561 AK293753 BAH11587 AK296237 BAG58956 AK299705 BAG61606 AK301803 BAG63254 BC000773 AAH00773 BC008080 AAH08080 BC008724 AAH08724 BC011657 BC020217 AAH20217 BC032676 BC034451 BC038446 AAH38446 BC069273 BQ230035 BU624935 BX095574 D26120 BAA05116 D26121 BAA05118 D26122 BAA05119 DC368015 DC370979 EU832634 ACE87725 EU832710 ACE87042 L49345 AAB03514 L49380 AAB04033 Y08765 CAA70018 Y08766 CAA70019 XM_011545244 XP_011543546 XM_011545245 XP_011543547 XM_011545246 XP_011543548 XM_011545247 XP_011543549 XM_011545248 XP_011543550 NM_001178030 NP_001171501 NM_001178031 NP_001171502 NM_004630 NP_004621 NM_201995 NP_973724 NM_201997 NP_973726 NM_201998 NP_973727 NR_033649 NR_033650 |
Function | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. {ECO:0000269|PubMed:7912130}. |
splicing factor 1 CRISPR/Cas9 KO Plasmid (h) - sc-405333 from Santa Cruz Biotechnology
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splicing factor 1 HDR Plasmid (h) - sc-405333-HDR from Santa Cruz Biotechnology
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splicing factor 1 Double Nickase Plasmid (h) - sc-405333-NIC from Santa Cruz Biotechnology
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splicing factor 1 Double Nickase Plasmid (h2) - sc-405333-NIC-2 from Santa Cruz Biotechnology
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splicing factor 1 CRISPR Activation Plasmid (h) - sc-405333-ACT from Santa Cruz Biotechnology
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splicing factor 1 CRISPR Activation Plasmid (h2) - sc-405333-ACT-2 from Santa Cruz Biotechnology
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splicing factor 1 Lentiviral Activation Particles (h) - sc-405333-LAC from Santa Cruz Biotechnology
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splicing factor 1 Lentiviral Activation Particles (h2) - sc-405333-LAC-2 from Santa Cruz Biotechnology
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splicing factor 1 siRNA (h) - sc-44115 from Santa Cruz Biotechnology
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splicing factor 1 shRNA Plasmid (h) - sc-44115-SH from Santa Cruz Biotechnology
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splicing factor 1 shRNA (h) Lentiviral Particles - sc-44115-V from Santa Cruz Biotechnology
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Splicing Factor 1 RNAi - H00007536-R02 from Novus Biologicals
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Splicing Factor 1 RNAi - H00007536-R03 from Novus Biologicals
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Splicing Factor 1 RNAi - H00007536-R01 from Novus Biologicals
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Splicing Factor 1 RNAi - H00007536-R04 from Novus Biologicals
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MISSION® esiRNA - EHU088611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19181 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08768 from Sigma-Aldrich
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SF1 siRNA (Human) - CRH5149 from Cohesion Biosciences
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SF1 - MBS8227976 from MyBioSource
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shRNA set against Human SF1 (NM_004630.3) - SHH405760 from Creative biogene
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SF1 shRNA Plasmid (Human) - CHH5149 from Cohesion Biosciences
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SF1 miRNA 3'UTR clone - MiUTR3H-04175 from Creative biogene
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SF1 miRNA 3'UTR clone - MiUTR3H-04176 from Creative biogene
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