Gene Symbol | UNC93B1 |
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Entrez Gene | 81622 |
Alt Symbol | IIAE1, UNC93, UNC93B, Unc-93B1 |
Species | Human |
Gene Type | protein-coding |
Description | unc-93 homolog B1 (C. elegans) |
Other Description | protein unc-93 homolog B1|unc-93 related protein|unc93 homolog B1 |
Swissprots | Q710D4 Q569H6 Q9H1C4 O95764 |
Accessions | AAD15416 EAW74676 EAW74677 Q9H1C4 AJ271326 CAC19791 AJ422142 CAD19522 AY007125 BC025669 AAH25669 BC033623 AAH33623 BC092472 AAH92472 BC101568 AAI01569 BC105104 AAI05105 BM969922 BM980538 BU622714 HY081711 XM_011545290 XP_011543592 XM_011545291 XP_011543593 NM_030930 NP_112192 |
Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. {ECO:0000269|PubMed:19006693}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}. |
Tissue Specificity | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. {ECO:0000269|PubMed:11867227, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}. |
UNC93B1 (E-12) - sc-135545 from Santa Cruz Biotechnology
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UNC93B1 (F-12) - sc-135546 from Santa Cruz Biotechnology
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Anti-UNC93B antibody - ab69497 from Abcam
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Anti-UNC93B antibody - ab115591 from Abcam
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Anti-UNC93B antibody - ab72123 from Abcam
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Anti-UNC93B / UNC93B1 Antibody (N-Terminus) IHC-plus⢠- LS-B2711 from LifeSpan Bioscience
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Anti-UNC93B / UNC93B1 Antibody (aa540-554) - LS-C47452 from LifeSpan Bioscience
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Anti-UNC93B / UNC93B1 Antibody (aa61-110) - LS-C81493 from LifeSpan Bioscience
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Anti-UNC93B / UNC93B1 Antibody - LS-C47404 from LifeSpan Bioscience
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UNC93B Antibody - NBP2-24743 from Novus Biologicals
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UNC93B Antibody - NBP1-76893 from Novus Biologicals
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UNC93B Antibody - NBP1-50279 from Novus Biologicals
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UNC93B Antibody - NBP2-13507 from Novus Biologicals
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UNC93B Antibody - H00081622-A01 from Novus Biologicals
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UNC93B Polyclonal Antibody - bs-8504R from Bioss
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Anti-UNC93B1 antibody produced in rabbit - AV49979 from Sigma-Aldrich
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Anti-Unc93b antibody produced in rabbit - PRS4553 from Sigma-Aldrich
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Anti-UNC93B1 antibody produced in rabbit - HPA042803 from Sigma-Aldrich
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UNC93B1 antibody - N-terminal region (ARP49979_T100) - ARP49979_T100 from Aviva Systems Biology
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UNC93B1 antibody - 70R-1820 from Fitzgerald
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Unc93b antibody - orb74971 from Biorbyt
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UNC93B1 Antibody (OALA02811) - OALA02811 from Aviva Systems Biology
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UNC93B1 (N-term) antibody - AP22608PU-N from Acris Antibodies
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UNC93B1 antibody - AP30977PU-N from Acris Antibodies
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UNC93B1 antibody - H00081622-A01 from Acris Antibodies
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