UNC93B1

Gene Symbol UNC93B1
Entrez Gene 81622
Alt Symbol IIAE1, UNC93, UNC93B, Unc-93B1
Species Human
Gene Type protein-coding
Description unc-93 homolog B1 (C. elegans)
Other Description protein unc-93 homolog B1|unc-93 related protein|unc93 homolog B1
Swissprots Q710D4 Q569H6 Q9H1C4 O95764
Accessions AAD15416 EAW74676 EAW74677 Q9H1C4 AJ271326 CAC19791 AJ422142 CAD19522 AY007125 BC025669 AAH25669 BC033623 AAH33623 BC092472 AAH92472 BC101568 AAI01569 BC105104 AAI05105 BM969922 BM980538 BU622714 HY081711 XM_011545290 XP_011543592 XM_011545291 XP_011543593 NM_030930 NP_112192
Function Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. {ECO:0000269|PubMed:19006693}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.
Tissue Specificity Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. {ECO:0000269|PubMed:11867227, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.

UNC93B1 (E-12) - sc-135545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
UNC93B1 (E-12): sc-135545. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

UNC93B1 (F-12) - sc-135546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-UNC93B antibody - ab69497 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 :  Anti-UNC93B antibody (ab69497) at 0.5 µg/mlLane 2 :  Anti-UNC93B antibody (ab69497) at 1 µg/mlLane 1 : human heart tissue lysateLane 2 : human heart tissue lysateLysates/proteins at 15 µg per lane.SecondaryAnti-rabbit

Anti-UNC93B antibody - ab115591 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115591, at 5 µg/ml, staining UNC93B in formalin fixed, paraffin embedded Human Skeletal Muscle by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated goat anti-rabbit secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-UNC93B antibody - ab72123 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UNC93B antibody (ab72123) at 4 µg/mlLane 1 : Human spleen lysate Lane 2 : Human spleen lysate plus immunising peptideLane 3 : Mouse spleen lysate

Anti-UNC93B / UNC93B1 Antibody (N-Terminus) IHC-plus™ - LS-B2711 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UNC93B1 / UNC93B antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2711 concentration 5 ug/ml.

Anti-UNC93B / UNC93B1 Antibody (aa540-554) - LS-C47452 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-UNC93B / UNC93B1 Antibody (aa61-110) - LS-C81493 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-UNC93B / UNC93B1 Antibody - LS-C47404 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of UNC93B in human spleen lysate in the 1) absence and 2) presence of immunizing peptide, and 3) mouse spleen lysate, using antibody at 4 ug/ml.

UNC93B Antibody - NBP2-24743 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: UNC93B Antibody [NBP2-24743] - Analysis of UNC93B in human spleen lysate in the 1) absence and 2) presence of immunizing peptide, and 3) mouse spleen lysate, using this antibody.

UNC93B Antibody - NBP1-76893 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: UNC93B Antibody [NBP1-76893] - Human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.

UNC93B Antibody - NBP1-50279 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: UNC93B Antibody [NBP1-50279] - Analysis of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.

UNC93B Antibody - NBP2-13507 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UNC93B Antibody [NBP2-13507] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG sp

UNC93B Antibody - H00081622-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

UNC93B Polyclonal Antibody - bs-8504R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat liver labeled with Anti UNC93B Polyclonal Antibody, Unconjugated (bs-8504R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-UNC93B1 antibody produced in rabbit - AV49979 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV49979</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 5.0 μg/mL in cell type Jurkat

Anti-Unc93b antibody produced in rabbit - PRS4553 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-Unc93b: <B>Cat. No. PRS4553</B> Immunohistochemistry of Unc93b in human heart with Unc93b antibody at 2.5 μg/mL.

Anti-UNC93B1 antibody produced in rabbit - HPA042803 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UNC93B1:<B>Cat. No. HPA042803</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

UNC93B1 antibody - N-terminal region (ARP49979_T100) - ARP49979_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC93B1 antibody - 70R-1820 from Fitzgerald

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Unc93b antibody - orb74971 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human heart tissue lysate at (A) 0.5 and (B) 1 ug/mL using Unc93b antibody

UNC93B1 Antibody (OALA02811) - OALA02811 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

UNC93B1 (N-term) antibody - AP22608PU-N from Acris Antibodies

Prices $430.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with UNC93B antibody AP22608PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

UNC93B1 antibody - AP30977PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Unc93b in human heart with AP30977PU-N at 2.5 μg/ml.

UNC93B1 antibody - H00081622-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
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