UNC93B1

Gene Symbol UNC93B1
Entrez Gene 81622
Alt Symbol IIAE1, UNC93, UNC93B, Unc-93B1
Species Human
Gene Type protein-coding
Description unc-93 homolog B1 (C. elegans)
Other Description protein unc-93 homolog B1|unc-93 related protein|unc93 homolog B1
Swissprots Q710D4 Q569H6 Q9H1C4 O95764
Accessions AAD15416 EAW74676 EAW74677 Q9H1C4 AJ271326 CAC19791 AJ422142 CAD19522 AY007125 BC025669 AAH25669 BC033623 AAH33623 BC092472 AAH92472 BC101568 AAI01569 BC105104 AAI05105 BM969922 BM980538 BU622714 HY081711 XM_011545290 XP_011543592 XM_011545291 XP_011543593 NM_030930 NP_112192
Function Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. {ECO:0000269|PubMed:19006693}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.
Tissue Specificity Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. {ECO:0000269|PubMed:11867227, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.

UNC93B1 CRISPR/Cas9 KO Plasmid (h) - sc-404369 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 HDR Plasmid (h) - sc-404369-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 Double Nickase Plasmid (h) - sc-404369-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 Double Nickase Plasmid (h2) - sc-404369-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 CRISPR Activation Plasmid (h) - sc-404369-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 CRISPR Activation Plasmid (h2) - sc-404369-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 Lentiviral Activation Particles (h) - sc-404369-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 Lentiviral Activation Particles (h2) - sc-404369-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC93B1 siRNA (h) - sc-97050 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC93B1 shRNA Plasmid (h) - sc-97050-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC93B1 shRNA (h) Lentiviral Particles - sc-97050-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC93B RNAi - H00081622-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU150171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22507 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22507 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04173 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04173

UNC93B1 siRNA (Human) - CRJ3030 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC93B1 - MBS8206199 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UNC93B1(NM_030930.2) - SHL115174 from Creative biogene

Category siRNA
Species Reactivities Human

UNC93B1 shRNA Plasmid (Human) - CHJ3030 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UNC93B1 miRNA 3'UTR clone - MiUTR1H-11017 from Creative biogene

Species Reactivities Human
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