| Gene Symbol |
UNC93B1
|
| Entrez Gene |
81622
|
| Alt Symbol |
IIAE1, UNC93, UNC93B, Unc-93B1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-93 homolog B1 (C. elegans)
|
| Other Description |
protein unc-93 homolog B1|unc-93 related protein|unc93 homolog B1
|
| Swissprots |
Q710D4 Q569H6 Q9H1C4 O95764
|
| Accessions |
AAD15416 EAW74676 EAW74677 Q9H1C4 AJ271326 CAC19791 AJ422142 CAD19522 AY007125 BC025669 AAH25669 BC033623 AAH33623 BC092472 AAH92472 BC101568 AAI01569 BC105104 AAI05105 BM969922 BM980538 BU622714 HY081711 XM_011545290 XP_011543592 XM_011545291 XP_011543593 NM_030930 NP_112192
|
| Function |
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. {ECO:0000269|PubMed:19006693}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.
|
| Tissue Specificity |
Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. {ECO:0000269|PubMed:11867227, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.
|