PAN2

Gene Symbol PAN2
Entrez Gene 9924
Alt Symbol USP52
Species Human
Gene Type protein-coding
Description PAN2 poly(A) specific ribonuclease subunit
Other Description PAB-dependent poly(A)-specific ribonuclease subunit 2|PAB-dependent poly(A)-specific ribonuclease subunit PAN2|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 2|PAN deadenylation complex catalytic subunit 2|PAN2 poly(A) specific ribonuclease subunit homolog|PAN2 polyA specific ribonuclease subunit|inactive ubiquitin carboxyl-terminal hydrolase 52|ubiquitin specific peptidase 52|ubiquitin specific protease 52
Swissprots Q76E12 O75189 Q504Q3 Q8IVE1
Accessions EAW96928 EAW96929 EAW96930 EAW96931 EAW96932 Q504Q3 AB014610 BAA31685 AB107585 BAD02263 AK001232 BAG50873 AK096679 AK310822 BC024043 AAH24043 BC094885 AAH94885 BX648106 DB290197 DB458902 NM_001127460 NP_001120932 NM_001166279 NP_001159751 NM_014871 NP_055686
Function Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618}.
Subcellular Location Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm.
Top Pathways RNA degradation

USP52 (C-20) - sc-82110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
USP52 (C-20): sc-82110. Western blot analysis of USP52 expression in HeLa (A), Jurkat (B) and K-562 (C) whole cell lysates.

Anti-Pan2 antibody - ab129797 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Pan2 antibody (ab129797) at 1/100 dilution + ZR-75-1 cell lysate at 35 µg

Anti-PAN2 antibody - ab56887 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56887 USP52 antibody at 1ug/ml.

Anti-Pan2 antibody - ab184138 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Pan2 antibody (ab184138) at 1/500 dilutionLane 1 : Jurkat whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Pan2 antibody - C-terminal - ab155821 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Pan2 antibody - C-terminal (ab155821) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-PAN2 / USP52 Antibody (aa859-888, AP) - LS-C216598 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa859-888, APC) - LS-C216599 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa859-888, Biotin) - LS-C216601 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa859-888, FITC) - LS-C216602 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa859-888, Azide-free, HRP) - LS-C216603 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa859-888, PE) - LS-C216604 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa859-888) - LS-C329946 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAN2 / USP52 Antibody (aa860-888) - LS-C163352 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PAN2 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The PAN2 antibody detected the PAN2 protein (arrow).

USP52 Antibody - NBP2-15062 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: USP52 Antibody [NBP2-15062] - Sample (30 ug of whole cell lysate) A: Jurkat 5% SDS PAGE; antibody diluted at 1:1000.

USP52 Antibody (6A7) - H00009924-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A7

USP52 Antibody - H00009924-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-PAN2 (C-terminal) antibody produced in rabbit - SAB2701341 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PAN2 (C-terminal): <B>Cat. No. SAB2701341</B>: Western Blot analysis of PAN2 in extracts from <B>Lanes</B><BR/>A. Jurkat using <B>Cat. No. SAB2701341</B> at a 1:1000 dilution.

Monoclonal Anti-USP52 antibody produced in mouse - WH0009924M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A7
<B>Immunoblotting</B><BR/>Monoclonal Anti-USP52, <B>Cat. No. WH0009924M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-USP52 (221-235) antibody produced in rabbit - U1510 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-USP52 (221-235): <B>Cat. No. U1510</B>: Immunofluorescence of HUVEC cells using USP52 (221-235) (RB),<B>Cat. No. U1510</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

PAN2-Antibody-C-term - AP16665b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PAN2 Antibody (C-term) (Cat. #AP16665b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the PAN2 antibody detected the PAN2 protein (arrow).

USP52-Antibody-monoclonal-M01 - AT4496a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

PAN2 Antibody - C-terminal region (OAAB12082) - OAAB12082 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PAN2 antibody - 70R-19104 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

USP52 / PAN2 antibody - 16427-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human heart using 16427-1-AP(PAN2 antibody) at dilution of 1:50 (under 10x lens)

USP52 / PAN2 (C-term) antibody - AP53157PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of USP52 / PAN2 Antibody (C-term) Cat.-AP53157PU-N in ZR-75-1 cell line lysates (35ug/lane). This demonstrates the PAN2 antibody detected the PAN2 protein (arrow)
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