PAN2

Gene Symbol	PAN2
Entrez Gene	9924
Alt Symbol	USP52
Species	Human
Gene Type	protein-coding
Description	PAN2 poly(A) specific ribonuclease subunit
Other Description	PAB-dependent poly(A)-specific ribonuclease subunit 2|PAB-dependent poly(A)-specific ribonuclease subunit PAN2|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 2|PAN deadenylation complex catalytic subunit 2|PAN2 poly(A) specific ribonuclease subunit homolog|PAN2 polyA specific ribonuclease subunit|inactive ubiquitin carboxyl-terminal hydrolase 52|ubiquitin specific peptidase 52|ubiquitin specific protease 52
Swissprots	Q76E12 O75189 Q504Q3 Q8IVE1
Accessions	EAW96928 EAW96929 EAW96930 EAW96931 EAW96932 Q504Q3 AB014610 BAA31685 AB107585 BAD02263 AK001232 BAG50873 AK096679 AK310822 BC024043 AAH24043 BC094885 AAH94885 BX648106 DB290197 DB458902 NM_001127460 NP_001120932 NM_001166279 NP_001159751 NM_014871 NP_055686
Function	Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618}.
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PAN2 overexpression lysate - LY402390 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PAN2 overexpression lysate - LY426794 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PAN2 293 Cell Lysate - 402097 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

USP52 Overexpression Lysate (Native) - NBL1-14090 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PAN2 Over-expression Lysate Product - GWB-261603 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human PAN2 Knockdown Stable Cell Line - CSC-DC011274 from Creative biogene Category Cell Line Species Human

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