| Gene Symbol | PAN2 |
|---|---|
| Entrez Gene | 9924 |
| Alt Symbol | USP52 |
| Species | Human |
| Gene Type | protein-coding |
| Description | PAN2 poly(A) specific ribonuclease subunit |
| Other Description | PAB-dependent poly(A)-specific ribonuclease subunit 2|PAB-dependent poly(A)-specific ribonuclease subunit PAN2|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 2|PAN deadenylation complex catalytic subunit 2|PAN2 poly(A) specific ribonuclease subunit homolog|PAN2 polyA specific ribonuclease subunit|inactive ubiquitin carboxyl-terminal hydrolase 52|ubiquitin specific peptidase 52|ubiquitin specific protease 52 |
| Swissprots | Q76E12 O75189 Q504Q3 Q8IVE1 |
| Accessions | EAW96928 EAW96929 EAW96930 EAW96931 EAW96932 Q504Q3 AB014610 BAA31685 AB107585 BAD02263 AK001232 BAG50873 AK096679 AK310822 BC024043 AAH24043 BC094885 AAH94885 BX648106 DB290197 DB458902 NM_001127460 NP_001120932 NM_001166279 NP_001159751 NM_014871 NP_055686 |
| Function | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618}. |
| Subcellular Location | Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm. |
| Top Pathways | RNA degradation |